舍格伦综合症患者唾液AST、LDH测定及临床意义

Salivary AST and LDH level with Sjogren's syndrome and its clinical significance

目的 探讨唾液中谷草转氨酶(AST)、乳酸脱氢酶(LDH)含量与舍格伦综合症(SS)的关系。方法采用酶连续监测法测定30例经临床确诊的SS患者、正常对照组及常见口腔粘膜病组唾液AST、LDH含量。结果SS患者唾液中AST、LDH平均含量分别为134.9U/L和275.0U/L,均明显高于正常对照组和疾病对照组的平均含量。酶含量异常率u检验,SS组的异常率明显高于常见口腔粘膜疾病对照组(P<0.01)。结论 SS患者唾液中AST、LDH明显增高,在一定程度上反映了SS的病变情况,与SS严重程度的关系有待进一步研究。

Objective To investigate the relationship between the salivary AST and LDH level and Sjogren's syndrome (SS). Methods Salivary AST and LDH level were measured by successive- enzymatic analysis in 30 patients with Sjogren's syndrome, other oral mucosal diseases and normal controls. Results The salivary AST and LDH level in SS groups were 134.9U/L and 275.0U/L respectively,which were significantly higher than that of the other two groups ( P < 0. 01). Conclusion The salivary AST and ADH level were significantly increased, which may indicate the degree of the lesion in SS.The relationship between the lesion and enzymatic level need to be further investigated.