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肿瘤坏死因子α在2型肥胖糖尿病患者中的作用 被引量：1

Effect of Tumor Necrosis Factor-αon Obese Patients with Type2Diabetes Mellitus
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摘要 目的 :探讨肿瘤坏死因子α在肥胖的2型糖尿病患者中的作用。方法:用双抗体夹心ELISA法检测肥胖、非肥胖的2型糖尿病患者和健康成人血清中肿瘤坏死因子α的水平。结果 :肥胖的2型糖尿病患者血清中肿瘤坏死因子α的表达水平明显高于非肥胖组与对照组 ,且与体重指数呈明显的正相关 ,与胰岛素敏感性指数呈负相关。结论 Objective:To study the effect of tumor necrosis factor-α(TNF-α)on obese patients with type2diabetes mellitus(DM).Methods:The expressions of TNF-αin the serum of obese and non-obese patients with type2diabetes mellitus and healthy people were tested with enzyme-linked immune sorbent assay(ELISA).Results:The expression of TNF-αin obese patients with type2DM was higher than that in non-obese patients with type2DM and healthy people,and it was strongly positive correlative with BMI and negaˉtive with insulin sensitivity index.Conclusion:The TNF-αhas an important effect on obesity-associated inˉsulin resistance.
作者 朱立荣 刘德敏 石建党 于德民 汤新之
机构地区 天津医科大学代谢病医院
出处 《天津医药》 CAS 北大核心 2003年第7期428-430,共3页 Tianjin Medical Journal
关键词 肥胖 2型糖尿病 肿瘤坏死因子Α 胰岛素 抗药性 双抗体夹心ELISA法 insulin resistance diabetes mellitus,non_insulin_dependent tumor necrosis factor-α
分类号 R589.2 [医药卫生—内分泌] R587.1 [医药卫生—内分泌]
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参考文献7

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二级参考文献3

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共引文献44

同被引文献7

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引证文献1

天津医药
2003年 第7期

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