摘要
用荧光光谱法研究了水溶液中抗癌药物丝裂霉素C、阿霉素与过氧化氢酶分子间的结合反应。结果表明 :药物对过氧化氢酶的内源荧光有较强的猝灭作用 ,形成复合物所产生的静态猝灭是引起过氧化氢酶荧光猝灭的主要原因。进一步依据荧光猝灭结果确定了药物
The binding characteristics of anticancer drug, mytomycin C (MMC) and adriamycn (ADM) with catalase were studied by fluorescence spectroscopy in aqueous solution. It was shown that both MMC and ADM have a strong ability to quench the catalase intrinsic fluorescence through a static quenching mechanism. The forming constants K A were further calculated according to the fluorescence quenching results.
出处
《化学通报》
CAS
CSCD
北大核心
2003年第7期496-499,共4页
Chemistry
基金
国家自然科学基金 ( 2 0 1730 5 0 )
湖南省自然科学基金 ( 0 1JJY30 0 9)资助项目
