摘要
A bridged bicydic compound (7), the key intermediate for the synthesis of ( - )-huperzine A (1), was prepared by diastereos-elective Michael-aldol annulation of β-keto ester (4) catalyzed by chiral guanidine (2). A variety of chiral catalysts, substrates and reaction conditions were tested.
A bridged bicydic compound (7), the key intermediate for the synthesis of ( - )-huperzine A (1), was prepared by diastereos-elective Michael-aldol annulation of β-keto ester (4) catalyzed by chiral guanidine (2). A variety of chiral catalysts, substrates and reaction conditions were tested.
基金
Project supported by Chinese Academy of Sciences and the National Natural Science Foundation of China(No.29725205).
