摘要
The stereoselecfive synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by CUM, 8-sphingadienine, a-hydroxy acid and a saccharide head. It was the first time that cerebrosides were isolated from this traditional Chinese medicine (TCM) by us. In this paper, C18-4, 8-sphingadienine was synthesized from D-xylose via a SN2 type reaction. α-Hydroxy add was prepared from (R )-4-hydroxyte-trahydrofuran-2-one, which in turn could be obtained from L-ascorbic acid.
The stereoselecfive synthesis of typhoniside, a new cerebroside isolated from Typhonium giganteum Engl. was accomplished. Cerebrosides are a kind of glycolipids highly enriched on the surface of myelin-producing cells and are composed by CUM, 8-sphingadienine, a-hydroxy acid and a saccharide head. It was the first time that cerebrosides were isolated from this traditional Chinese medicine (TCM) by us. In this paper, C18-4, 8-sphingadienine was synthesized from D-xylose via a SN2 type reaction. α-Hydroxy add was prepared from (R )-4-hydroxyte-trahydrofuran-2-one, which in turn could be obtained from L-ascorbic acid.
基金
Project supported by the National Natural Science Foundation of China(No.29790126),Chinese Academy of Sciences(No.95-A1504-03)and the Ministry of Science and Technology of China(Nos.970211006-6,G2000077502).
