摘要
目的:验证金橘开胃颗粒剂治疗小儿厌食脾失健运证的有效性与安全性。方法:采用随机分组、平行对照的方法进行临床对照研究。结果:试验组的愈显率为76.86%,明显高于对照组(P<0.001)。试验组食欲不振、食量减少、异常舌脉的消失率,以及治疗前后证候积分总值差值,均明显高或大于对照组(P<0.01~0.001)。治疗后,两组周围血HB含量和RBC数均较治疗前明显升高(P<0.001~0.05),且试验组HB的治疗前后差值明显大于对照组(P<0.05);两组患儿尿D-木糖排泄率均值与治疗前比较均有明显提高(P<0.001和P<0.05)。安全性指标观测未发现除轻度腹泻外的其他毒副反应。结论:金橘开胃颗粒剂对小儿脾失健运型厌食症具有较好的治疗作用,且临床应用比较安全。
Objective: To verify the effectiveness and reliability of Jinjukaiwei Granules in treating anorexia spleen fails to transport and transform syndrome in children. Method: 243 patients were randomly divided into two groups. Compared by parallel control. Results: The effective rate was 76.86% in the treated group, which was higher significantly than that in the control group (P<0.01). Both the disappearance rates of some symptoms including anorexia, poor appetite, abnormal tongue, pulse and the difference of total score between pre-treatment and post-treatment in the treated group were significantly higher than those in the control group (P<0.01~0.001). The content of HB and the RBC count were remarkably improved after treatment in both groups (P<0.001~0.05). The difference of HB between pre-treatment and post-treatment in the treated group was significantly higher than that in the control group (P<0.05); the excretory rates of D-xylose in urine were both significantly improved in two groups (P<0.001, P<0.05, respectively). The observation about reliability markers indicated: there was no other toxic and side effects except mild diarrhea. Conclusion: Jinjukaiwei Granules possesses better effects in treating anorexia spleen fails to transport and transform syndrome in children, during the reliability observation, which indicated the better clinical reliability.
出处
《中国中医药信息杂志》
CAS
CSCD
2003年第7期16-17,78,共3页
Chinese Journal of Information on Traditional Chinese Medicine
关键词
金橘开胃颗粒剂
中医药治疗
小儿
厌食
脾失健运证
安全性
Jinjukaiwei Granules
anorexia in children
spleen fails to transport and transform syndrome
salivary amylase
urine D-xylose test