老年高血压患者血压节律与靶器官损害相关性的研究

The sutdy of correlation between blood pressure rhythm and impairement in target organs of the elder patients with hypertension

目的 :探讨老年高血压病患者血压节律变化与心、脑、肾等靶器官损害的相关性。方法 :观察高血压病血压节律正常 (杓型组 )和异常 (非杓型组 ) 2组老年患者各 30例的临床资料。结果 :组间在体重指数、偶测血压、白昼平均收缩压等无显著差异 (P >0 .0 5 ) ;非杓型组 2 4 h平均收缩压和舒张压、白昼平均舒张压、夜间平均收缩压和舒张压、收缩压和舒张压负荷值较杓型组升高 (P <0 .0 5～ 0 .0 1) ;左室重量和左室重量指数显著增加 (P <0 .0 5 ,0 .0 1) ;无症状腔隙性脑梗塞的个数及发病率均高于后者 (P <0 .0 5 ) ;无痛性心肌缺血次数增多 ,总持续时间延长 (P <0 .0 1,0 .0 5 ) ;尿蛋白检出率亦高于后者 (P <0 .0 1)。结论

Objective:To study the correlation between blood pressure rhythm and impairement in target organs,such as heart,brain,kidney,etc.in elder patients with hypertension Methods:The patient's clinical data (each 30 cases)whose blood pressure rhythm were normal(group Ⅰ) and abnormal (group Ⅱ) were observed,respectively Results:There are no significantly difference (P>0 05) in body mass index,blood pressure measured by chance,average systolic pressure at daytime between two groups.Compared with the group Ⅰ,the group Ⅱ were higher in 24h average systolic and diastolic pressure,average diastolic pressure at daytime,average systolic and diastolic pressure during nighttime,the load values of systolic and diastolic pressure (P<0 05~0 01);The left ventricle weight and weight index significantly raised in group Ⅱ (P<0 05~0 01).Otherwise,the number and incidence rate of symptomless compartment cerebral infarction in group Ⅱ was higher than that in group Ⅰ (P<0 05);the number of times of painless myocardial ischemia increased,and the total lasted time clongated in group Ⅱ,also.The identification rate of urine protein in group Ⅱ was higher than that in group Ⅰ (P<0 01) Conclusion:Compared with the normal rhythm of blood pressure between day and night,There are more marked impaired in target organs in those whose rhythm of blood pressure were abloition in the hypertension patients