羟基喜树碱为主治疗耐药非小细胞肺癌的疗效观察

Effect of hydroxycamptothecin on drug resistant non-small cell lung cancer

目的 :观察羟基喜树碱 (HCPT)为主的方案治疗耐药非小细胞肺癌的疗效。方法 :选择耐药晚期肺癌 4 5例 ,随机分为 A、B两组 ,A组 2 2例 ,B组 2 3例 ,A组给予顺铂 (DDP) 6 0 m g/ m2 ,第 1天 ,HCPT10 m g/天 ,第 1～ 5天 ,4周为一个周期 ,连用 3个周期。B组给予 NVB+DDP化疗 ,去甲长春花碱 (NVB) 2 5 m g/ m2 ,第 1、8、15天 ,DDP6 0 mg/ m2 ,第 1天 ,4周为一个周期。结果 :A组 9例、B组 2例在化疗第 1个周期后达 PR,A组和 B组总有效率分别为 4 0 .9%和 8.7% (P <0 .0 5 )。第二周期后 ,A组和 B组总有效率分别为 4 5 .5 %和 13.0 % (P <0 .0 5 )。第三周期后 ,A组 1例达到 CR,但总有效率与第二周期相同。A组中位生存期8个月。B组中位生存期 5个月。毒性反应主要是白细胞和血小板减少。结论 :羟基喜树碱可用于耐药晚期肺癌的治疗 。

Objective:To observe the efficacy of hydroxycamptothecin(HCPT)+DDP in the treatment of drug resistant non small cell lung cancer Methods:Forty five patients with drug resistant lung cancer were divided randomly into group A and group B.Twenty two treated by HCPT+DDP in group A,DDP 60mg/m 2 on d1 and 10mg of HCPT on d1 5,and twenty three treated by NVB+DDP in group B,DDP 60mg/m 2 on d1,NVB 25mg/m 2 on d1,8,15,a cycle every 4 weeks and three cycles were given in two groups Results:Nine patients in group A and two patients in group B showed partial remission (PR) after the first cycle,the overall response rate (ORR) were 40 9% and 8 7% respectively (P<0 05).The ORR was 45 5%(10PR) in group A and 13 0%(3PR) in group B (P<0 05) after the second cycle and 45 5%(1CR,9PR) in group A and 13 0%(3PR) in group B (P<0 05) after the third cycle.The major toxicity was leukopenia and thrombocytopenia Conclusion:The regimen of HCPT+DDP is effective on drug resistant lung cancer and the side effects are tolerable