兔脑垂体注射液的大鼠长期毒性实验研究

Toxicity Study of Rabbit Pituitary Injection

目的 :观察兔脑垂体注射液的急性毒性与长期毒性。方法 :小鼠尾静脉注射给予兔脑垂体注射液 1次后观察其急性毒性 ;大鼠以兔脑垂体注射液 0 .5ml·kg-1,0 .2 5ml·kg-1,0 .1ml·kg-13种剂量 ,每日 1次 ,连续 3个月对大鼠腹腔注射给药以及停药后 2周 ,与对照组比较 ,考察大鼠的一般状态、生长发育、造血功能、肝脏功能、肾脏功能和重要器官重量系数等的影响。结果 :急性毒性实验表明 :小鼠未出现异常反应 ,其最大耐受量为 2 4ml·kg-1,相当于临床人用剂量的 30 0倍。长期毒性实验表明 :未见动物出现外观、体重增长和血象、肝肾功能及所考察脏器组织的毒性作用。结论 :兔脑垂体注射液的毒性较低。

Objective: To observe the acute toxicity and long term toxicity of rabbit pituitary injection.Method: To inject rabbit pituitary injection for mice once via tail vein and observe its acute toxicity. Rats were given rabbit pituitary injection as dose 0.5 ml·kg -1, 0.25 ml·kg -1, 0.1 ml·kg -1 for three months via abdomen cavity and observe its long term toxicity.Result: The acute toxicity showed that the max tolerance dose of rabbit pituitary injection was 24 ml·kg -1, which corresponded to 300 times of human dose. The long term toxicity showed that the rats weren't be found the changes of appearance, weight, blood, liver, kidney and other visceras.Conclusion: The toxicity of the rabbit pituitary injection is very lower.