不同剂量胺碘酮治疗老年人心房颤动的临床疗效及安全性

Clinical Efficay and Safety of Different Doses Amiodarone on Elder-aged Patients with Atrial Fibillation

目的 :评价不同剂量胺碘酮用于老年房颤患者的临床疗效及安全性。方法 :4 5例老年房颤患者随机分为A、B两组 ,胺碘酮剂量用法分别为 0 .2 gbid和0 .2 gtid。结果 :A、B两组平均血药谷浓度分别为 370 .6 4± 14 2 .19ng·ml-1,6 33.35±335 .87ng·ml-1,两组有显著差异。平均完全复律时间分别为 11.5 7± 3.99d ,8.4 4± 4 .0 5d ,两组有显著差异。复律率分别为6 3.6 4 % ,78.2 6 % ,两组无显著差异。 4 5例患者中 12例发生不良反应 ,发生率为 2 6 .6 7%。结论 :胺碘酮治疗老年房颤的疗效确切 ,在预防血栓的同时可予 0 .2 gtid用于复律 ,用0 .2 gqd维持窦律 ,预防复发。

Objective: To evaluate the effect and safety of different dosages amiodarone for elder patients with atrial fibillation.Method: A study was performed in 45 patients with atrial fibillation. All patients were divided randomly to two groups(A,B). The drug administration was 0.2 bid or 0.2 tid, respectively. Result: The serum concentrations in both groups were 370.64± 142.19, 335.87± 335.35 (ng·ml -1), respectively. There was significant different in the serum concentration between the A and B.The conversion time of atrial fibillation was 11.57± 3.99 or 8.44± 4.05(days), which had significat difference. The conversion rates of atrial fibillation was 63.64% or 78.26%, respectively, which had no significat difference. The conversion of atrial fibillation related with the total dosage. 12 patients occured advrse effects in 45 patients.Conclusion: Amiodarone is an effective and safe drug in treating older patients with atrial fibillation.