晕船大鼠体内铁含量的变化

Change of contents of iron in the seasickness rats

目的 探讨模拟晕船条件下大鼠机体组织铁含量和尿铁排出的变化。方法 将SD大鼠随机分为晕船组和对照组 ,原子吸收分光光度法检测大鼠血清、尿液和部分器官中铁元素的含量。结果 血清、肝脏、大脑、小脑、肾上腺铁含量在对照组依次为 (46 9± 3 5) μmol/L、(94 9± 8 5) μg/g、(3 8 5± 7 5) μg/g、(86 9± 9 5) μg/g、(159 9± 2 1 6) μg/g ,在晕船组依次为 (2 8 1± 4 8) μmol/L、(47 9± 9 1) μg/g、(2 3 6± 6 1) μg/g、(53 0± 8 7) μg/g、(2 96 2± 2 6 5) μg/g ,两组比较 ,差异均具有统计学意义 ;与对照组相比 ,尿液铁在旋转第一天时 ,晕船组大鼠排出量显著减少 ,为 (40 1 4± 2 6 7) μg/d ,第二、三天时显著性增多 ,分别为 (750 7± 2 4 1) μg/d ,(764 3± 2 7 9) μg/d ;而心脏、脑干、下丘脑铁含量与对照组相比有升高的趋势 ,但差异无统计学意义。结论 晕船可能影响大鼠机体铁元素的分布 ,这种变化在晕船发生中的作用值得进一步探索。

Objective The study was conducted to quanti tively investigate the content of iron in various tissues and in urine in the rats with simulated seasickness. Methods Twenty five SD rats w ere divided into the normal control and the seasickness groups randomly, the con tent of iron in serum, urine and organs was determined with atomic absorption sp ectrophotometry. Results The contents of iron in serum, liver, cerebrum, cerebellum, adrenal gland in the seasickness group were much higher th an those of the normal control. On the 1st day of rotation, the content of iron in urine of seasickness rats was decreased remarkably, whereas increased on the 2nd and the 3rd day of rotation. Contrasting to the normal control, there was tend ency to increase of iron contents in heart, brain stem and hypothalamus in seas ickness rats. Conclusion Seasickness could influence the distr ibution of the iron in rat.