摘要
采用热电偶探针测温系统 ,研究了运用JC A型HIFU聚焦超声肿瘤治疗系统定点辐照新鲜离体牛肝脏的生物学焦域温场分布。研究结果表明 :焦域中心温度最高 ,温升可达 74 .4± 1.5℃。在空间上 ,远离焦点温升快速下降 ,Z轴有效温升宽度 12 .4mm ,X、Y轴有效温升宽度均为 5 .4mm。X、Y、Z轴有效温升宽度与生物学焦域大小一致。光镜下 ,生物学焦域与周围正常组织分界清楚。所以 ,在空间上 ,由生物学焦域中心向外缘 ,能量递减十分陡峭 ,具有“刀”的特征。高强度聚焦超声对深部组织定位损伤在空间上是精确的、有效的、安全的。
To discuss the accuracy, efficacy, safety of high intensity focused ultrasound (HIFU) tissue destruction, we studied the temperature field of biological focal region (BFR) induced by (HIFU) in freshly excised cow liver using thermocouple probe. The results showed that the maximum temperature rise in the center of BFR was 74.4 ± 1.5°C. Temperature rise far away from focus on X, Y, Z-axis dropped rapidly within BFR. Effective temperature rise width (ETRW) was 12.4mm on Z-axis, and 5.4mm on X and Y-axis. The ETRW was consistent with the size of the BFR on X, Y and Z-axis. The sharp boundary between the BFR and normal liver was visible on light microscopy, showing thermal dose decreasing acutely outwards from BFR center to normal tissue spatially, resembling a 'knife'. So HIFU can accurately, effectively, safely ablate tumor within the body.
出处
《中国生物医学工程学报》
EI
CAS
CSCD
北大核心
2003年第4期321-325,共5页
Chinese Journal of Biomedical Engineering
基金
国家自然科学基金资助项目 ( 3 0 0 70 3 17
3 963 0 3 40 )
