原发性肝癌和肝硬化患者触珠蛋白测定的临床意义

Clinical significance of haptoglobin determined of patient with primary hepatic cancer and hepatic cirrhosis

目的 探讨原发性肝癌和肝硬化患者血清触珠蛋白水平测定的临床意义及其机制。方法 血清触珠蛋白测定采用速率散射比浊法 (RatenNephemometry)。结果 各肝病组血清触珠蛋白水平都明显低于正常对照组 (P <0 .0 1 ) ,其中肝癌和肝硬化组下降最为明显 ,但肝硬化腹水合并感染患者触珠蛋白水平却明显升高 (P <0 .0 1 )。结论 肝病患者触珠蛋白下降的原因可能和肝实质的广泛受损、肝脏合成触珠蛋白功能低下以及溶血有关 。

Objective It is to explore the clinical significance and mechanism of the serum haptoglobin (HP) determined level of patient with primary hepatic cancer (PHC) and hepatic cirrhosis (HC). Methods Serum HP was determined with the method of Raten Nephelometry. Results The of serum HP level in each abnormal group, especially in PHC and HC group, was lower than that in normal control group ( P <0.01), while that of HC patients who suffered form infected ascites increased significantly ( P <0.01). Conclusion The lower HP level in patients with liver disease maybe concerned with widely damage of liver tissue, lower synthetising of HP in liver and hemolysis. The higher HP level maybe is helpful to diagnosis of the infection of ascites in HC patient.