摘要
ED50 of Pure Swainsonine (SW) to EMT6 cell strain is 1.2 (0.8-1.6) mg/L and the dose of entire lethal is 6.4 mg/L with MTT method. After ig crude extraction of SW to S180 sareoma rooted in mouse and EMT6 model mice with breast carcinoma for 12 d at dose of 16 mg/kg, the inhibitory rates of weight amounts to 49.7% and 49.4% respectively (P<0.01). Given crude extraction of SW at 4 mg/kg combined with irradiation at 5 Gy60Co-γ, the inhibitory rate of weight of S180 amount to 64.5% (P<0.01). It shows that SW has obviously antineoplastic.
ED50 of Pure Swainsonine (SW) to EMT6 cell strain is 1. 2 (0. 8 - 1. 6) mg/L and the dose of entire lethal is 6.4 mg/L with MTT method. After ig crude extraction of SW to S180 sareoma rooted in mouse and EMT6 model mice with breast carcinoma for 12 d at dose of 16 mg/kg, the inhibitory rates of weight amounts to 49. 7% and 49.4% respectively ( P < 0.01) . Given crude extraction of SW at 4 mg/kg combined with irradiation at 5 Gy 60Co-γ, the inhibitory rate of weight of S180 amount to 64. 5% (P <0. 01). It shows that SW has obviously antineoplastic.
