微量肝素对正常家兔血液流变性的影响

EFFECTS OF MICRODOSAGE OF HEPARIN ON HEMORHEOLOGY IN RABBITS

目的 :探讨微量肝素对正常家兔血液流变性的影响。方法 :家兔 40只 ,雌雄各半 ,随机均分为生理盐水对照组、0 .2 5U·kg-1 ·h-1 、0 .5U·kg-1 ·h-1 、1 .0U·kg-1 ·h-1 及 2 .0U·kg-1 ·h-1 肝素组。按 2ml·h-1 经耳缘静脉滴注给药和生理盐水 2h后经股动脉取血测定全血高、中、低切粘度 (Hηb、Mηb、Lηb)、血浆粘度 (ηp)、血沉 (ESR)、红细胞压积 (Hct)等血液流变性指标和血浆凝血酶原时间 (PT)、活化部分凝血酶原时间 (APTT)。结果 :1 .0U·kg-1 ·h-1 和2 .0U·kg-1 ·h-1 肝素组 ,全血高切粘度、低切粘度、还原粘度 (ηre)、红细胞聚集性和ESR均降低 ,红细胞电泳时间(EPT)延长 ,同对照组间差异具有显著性 (P <0 .0 5或 0 .0 1 )。 0 .2 5U·kg-1 ·h-1 和 0 .5U·kg-1 ·h-1 肝素组同对照组比较 ,血液粘度及血沉等差异无显著性。PT和APTT各组间无显著差异。结论 :1 .0U·kg-1 ·h-1 和 2 .0U·kg-1 ·h-1 微量肝素对正常家兔血液流变性有明显影响 。

Objective: To research the effects of microdosage of heparin on hemorheology in rabbits. Methods: 40 rabbits were divided into five groups at random. After heparin or 0.9% sodium chloride was given by intravenous instillation at the speed of 2ml·h -1 2 hours, blood samples were collected through catheter of femoral, which was used to measure hemorheological indexes?PT and APTT within 4 hours. Results: In 1.0 IU·kg -1 ·h -1 and 2.0 IU·kg -1 ·h -1 heparin groups, blood viscosity?blood reduced viscosity?index of RBC aggregation etc , markedly decreased and electrophoresis time of RBC significantly prolonged.(P<0.05 or 0.01 vs control group), But in 0.25 IU·kg -1 ·h -1 and 0.5 IU·kg -1 ·h -1 heparin groups, indexes of hemorheology had no significant change. PT and APTT had no statistical difference among the five groups. Conclusion: 1.0 u·kg -1 ·h -1 and 2.0u·kg -1 ·h -1 microdosage of heparin could significantly improve properties of hemorheology and had no serious effects on blood coagulation.