摘要
肾上腺素β3受体参与心脏和血管的生理调控心脏。β3受体兴奋表现为负性变力作用。心力衰竭时 ,β3受体含量明显增加 ,其负性肌力作用更显著 ,提示 β3受体在心功能恶化和心力衰竭进程中具有重要作用。
出处
《国外医学(生理病理科学与临床分册)》
2003年第3期280-282,共3页
Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
参考文献16
-
1Chantal G, Dominique L, Jean-Lue B. β3-adrenoceptors in the cardiovascular system[ J]. Trend Phama Science, 2000,21 ( 11 ) :426.
-
2Gauthier C, Tavernier G, Charpentier F, et al. Functional β3-adrenoceptor in human heart[J]. J Clin Invest, 1996,98(2) :556.
-
3Grarmeman JG, Lahners KN. Chaudhry A. Characterization of the humanβ3 -adrenoceptor receptor gene [ J ]. Mol Pharmaeol. 1993,44( 2 ) : 264-270.
-
4Gauthier C, Leblais V, Kobzik L, et al. The negative inotropic effect of beta 3-adrenoeeptor stimulation is mediated by activation of a nitrie oxide synthase pathway in human ventricle[ J]. J Clin Invest,1998,102(7) : 1377-1384.
-
5Chamberlain PD,Jennings KH, Paul F,et al. The tissue distribution of the humanβ3-adrenoceptors studied using a monoclonal antibody:direct evidence of the β3-adrenoceptors in human adipose tissue, atrium and skeletal muscle[ J]. Int J Obes Relat Metab Disord, 1999,23(10) :1057-1065.
-
6Kaumann A J, Molenaar P. Modulation of human cardiac function through 4 beta-adrenoceptor populations [ J ]. Naunyn Schmiedebergs Arch Pharmacol, 1997,355 (6) :667-681.
-
7Skeberdis VA. β3-adrenergic regulation of L-type calcium current in human atrial myocytes[ J]. Biophys J,2000,76:A343.
-
8Gauthier C,Tavernier G,Trochu JN ,et al. Interspeeies differences in the cardiac negative inotropic effects of β3-adrenoceptors agonists[ J]. J Pharmacol Exp Ther, 1999.290 ( 2 ) :687-693.
-
9Cheng HJ, Zhang ZS, Cheng CP, et al. Upregulation of functional β3-adrenergic receptors in the failing canine myocardium [ J ]. Circ Res,2001,89 (9) :599-606.
-
10Kitamura T,Onishi K,Dohi K,et al. The negative inotropic effect of beta3-adrenoceptor stimulation in the beating guinea pig heart [ J ]. J Cardiovascular Pharmacology ,2000,35 (5) :786-790.
-
1吴宗虎,孙宝贵.β_3肾上腺素受体与心血管疾病[J].心血管病学进展,2006,27(z1):32-34.
-
2叶绪英,卢成志.β_3肾上腺素受体对心功能的影响[J].国际心血管病杂志,2008,35(5):276-278. 被引量:1
-
3蒋淑君.β_3肾上腺素受体与脂肪代谢[J].医学理论与实践,2004,17(5):519-520.
-
4黄爱民.48例低血糖症的临床诊治分析[J].中国伤残医学,2015,23(3):167-167.
-
5崔然,陈枚洁,谢冰冰,安慧玲,缪国斌,徐援,王广,李晓红,孙继红,陈哲.β_3肾上腺素受体对老年性心力衰竭的影响[J].医学综述,2014,20(7):1167-1169. 被引量:3
-
6孔一慧,李为民.β_3-肾上腺素能受体在心血管系统中的研究进展[J].心血管病学进展,2002,23(5):292-294. 被引量:1
-
7朱春晓,顾勇.Na-KATPase与高血压[J].国外医学(泌尿系统分册),2000,20(3):99-100.
-
8邹延新,李宾公,张月华,吴茂礼.心肌梗塞后心力衰竭大鼠心脏β_3肾上腺素受体的表达及卡维地洛的影响[J].心血管康复医学杂志,2008,17(5):458-461. 被引量:1
-
9郭瑞峰.β3-肾上腺素受体W64R基因多态性与代谢综合征的相关性研究[J].疾病监测与控制,2008,2(5):253-254.
-
10薛浩,刘国树.β_3肾上腺素受体在心血管系统中的作用[J].国外医学(心血管疾病分册),2004,31(3):153-155. 被引量:1