期刊文献+

FGFs及其受体对胚胎器官发生的调控作用 被引量:1

下载PDF
导出
摘要 在胚胎器官形成过程中 ,成纤维细胞生长因子 (FGFs)是担负上皮 间质相互作用的重要调控因子 ,特别是FGF10 ,无论在外胚层上皮还是在内皮层上皮都是重要的间质调控因子。FGFs信号对早期胚胎、四肢、牙齿、肺 支气管、肝脏和胰腺、眼睑和皮肤、颅骨、下颌腺、中枢神经系统、骨骼肌、乳腺、外生殖器、泌尿器、骨骼。
机构地区 解放军第
出处 《国外医学(生理病理科学与临床分册)》 2003年第3期283-285,共3页 Foreign Medical Sciences(Pathophysiology and Clinical Medicine)
基金 国家重大基础研究规划 (G19990 54 2 0 4 ) 国家自然科学基金 ( 30 2 30 370 ) 国家杰出青年科学基金 ( 3952 50 2 4 ) 国家自然科学基金面上项目 ( 30 170 96 6 )
  • 相关文献

参考文献20

  • 1Li C, Guo H, Xu X, et al. Fibroblast growth factor receptor 2( FGFR2 ) plays an important role in eyelid and skin formation and patterning[ J ]. Dev Dyn ,2001,222 (3) :471-483.
  • 2Ota Y, Saitoh Y, Suzuki S, et al. Fibroblast growth factor 5 inhibits hair growth by blocking dermal papilla cell activation [ J ]. Biochem Biophys Res Commun ,2002,290( 1 ) : 169-176.
  • 3Ohbayashi N, Shibayama M, Kurotaki Y, et al. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis [ J ]. Genes Dey ,2002 , 16 ( 7 ): 870-879.
  • 4Pandit SG, Govindraj P, Sasse J, et al. The fibroblast growth factor receptor, FGFR3, forms gadients of intact and degaded protein across the growth plate of developing bovine ribs [ J ]. Biochem J,2002,361 ( Pt 2) :231-241.
  • 5Jaskoll T, Zhou YM, Chai Y, et al. Embryonic submandibular gland morphogenesis: stage-specific protein localization of FGFs,BMPs, Pax6 and Pax9 in normal mice and abnormal SMG phenotypes in FGFR2-Ⅲc( +/Delta), BMP7(-/-) and Pax6(-/-) mice[ J]. Cells Tissues Organs,2002,170(2-3) :83-98.
  • 6Lelievre V, Hu.Z, Byun JY,et al. Fibroblast growth factor-2 converts PACAP growth action on embryonic hindbrain precursors from stimulation to inhibition[J]. J Neurosci Res, 2002,67(5 ) :566 -573.
  • 7Mailleux AA, Spencer - Dene B, Dillon C,et al. Role of FGF10/FGFR2b signaling during mammary gland development in the mouse embryo [ J ]. Development, 2002,129 ( 1 ) :53 - 60.
  • 8Zammit C, Coope R, Gomm JJ,et al. Fibroblast growth factor 8 is expressed at higher levels in lactating human breast and in breast cancer [ J ]. Br J Cancer,2002,86 ( 7 ) : 1097 - 1103.
  • 9Suzuki K, Tokue A, Kamiakito T,et al. Predominant expression of fibroblast growth factor (FGF) 8, FGF4, and FGF receptor 1 in nonseminomatous and highly proliferative components of testicular germ cell tumors [ J ]. Virchows Arch,2001,439 (5) :616 - 621.
  • 10Haraguchi R, Mo R, Hui C, et al. Unique functions of Sonic hedgehog signaling during extemal genitalia development [ J ]. Development ,2001,128 : 4241 - 4250.

同被引文献19

  • 1Naz RK,Kumar G,Minhas BS.Expression and role of c-myc protooncogene in murine preimplantation embryonic-development[J].Assist Reprod Genet,1994,11(4):208-216.
  • 2Fan Y,Melhem MF,Chaillet JR.Forced expression of the homeobox-containing gene Pem blocks differentiation of embryonic stem cell[J].Dev Biol,1999,210:481.
  • 3Ke X,Warner CM.Regulation of the Ped gene expression by TAP protein[J].J Reprod Immunol,2000,46:1.
  • 4Rogers MB,Hosler BA,Gudas LJ.Specific expression of a retinoic acid-regulated,zinc-fingergene,Rex-1,in preimplantation embryos,trophoblast and spermatocytes[J].Dev Biol,1991,113:815.
  • 5Werb Z.Expression of EGF and TGF-α genes in early mammalian development[J].Mol Reprod Dev,1990,27:10-15.
  • 6Bouvier MM,Mytilineou C.Basic fibroblast growth factor increase division and delays differentiation of dopamine precursors in vitro[J].J Neurosci,1995,15:7141-7149.
  • 7Ye w,Shimamura K,Rubenstein JL,et al.FGF and Shh signals control dopaminergic and serotonergic cell fatein the anterior neural plate[J].Cell,1998,93:755-766.
  • 8Tsai HD,Chang CC,Hsieh YY,et al.Recombinant human leukemia inhibitory factor enhances the development of preimplantation mouse embryo in vitro[J].Fertil Steril,1999,71(4):722-725.
  • 9Shen MM,Leder P.Leukemia inhibitory factor is expressed by the preimplantation uterus and selectively blocks primitive ectoderm formation in vivo[J].Proc Natl Acad Sci USA,1992,89:8240.
  • 10李艳红,姚元庆,姚兵,黄威权,杨梦庚.原癌基因c-myc产物在小鼠早期胚胎中的表达[J].第四军医大学学报,2000,21(2):253-254. 被引量:1

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部