对氯苯基丙酮的合成

A New Process for 4-Chlorophenylacetone Synthesis

研究了以对氯氯苄为主要原料 ,合成药物中间体对氯苯基丙酮的新工艺。该工艺由对氯苄基氯化锌和苯基丙酮的两步合成反应组成。优化的工艺条件为n(对氯苄基氯 )∶n(Zn)∶n(乙酐 ) =1∶1.2∶2 .5 ;对氯苄基氯化锌的合成温度 60～ 65℃ ,反应时间3h ;对氯苯基丙酮合成温度 3 0～ 3 5℃ ,反应时间 5h。总收率 78%。

A new process for 4-chlorophenylacetone synthesis from organic zinc reagent and acetic anhydride was studied.The suitable conditions were determined by experiments such as mole rate,reaction temperature and reaction time.The over yield of 4-chlorophenylacetone achieved 78%.