摘要
盐酸安非他酮为一种抗抑郁药物。以间氯苯基乙酮为原料 ,经溴代 ,N -烃基化反应得盐酸安非他酮。在溴化反应中采用新型溴试剂 ,避免了直接溴代 ,溴代产率提高至 85 %。在N -烃基化反应中使用聚乙二醇作相转移剂 ,得到高产率产物 ,结构经IR ,1
Amfebutamone hydrochloride is an antidepressant.1-(3-chlorophenyl)-1-propanone takes for raw material.After through brominating,N-alkylation,the amfebutamone hydrochloride was obtained.A new bromizating agent was used in the brominating reaction.Immediate brominating was averted.The yield was over 85%.Polyethylene glycol(PEG)took for phase-transfer catalyst(PTC) in the N-alkylation reaction which good yields.The structures of the products were determined by IR, 1HNMR and elemental analysis.
出处
《山东化工》
CAS
2003年第3期3-5,共3页
Shandong Chemical Industry
关键词
盐酸安非他酮
溴试剂
相转移催化
合成
amfebatamone hydrochlorid
brominating agent
phase-transfer catalysis
synthesis
