代谢综合征患者空腹血清游离脂肪酸水平与胰岛素抵抗的关系

Relationship of fasting serum free fatty acids levels and insulin resistance in patients with metabolic syndrome

目的 探讨代谢综合征 (MS)患者空腹血清游离脂肪酸 (FFAs)水平与胰岛素抵抗的关系。方法 用发色底物法测定 60例MS患者及 2 0名正常人 (对照组 )的空腹血清FFAs浓度 ,比较两组间空腹血清FFAs水平及胰岛素敏感指数 (ISI)的差异 ;并将空腹血清FFAs水平及MS的其他特征性参数分别与ISI作相关性分析。结果 MS患者空腹血清FFAs水平为 ( 60 7.1± 2 17.8)μmol/L ,显著高于对照组 (P <0 .0 1) ;ISI为 -4 .5 8± 0 .49,显著低于对照组 (P <0 .0 1)。MS患者的ISI与FFAs呈显著负相关 (P <0 .0 5 ,r =-0 .3 2 9) ;ISI亦与BMI呈负相关。结论 代谢综合征患者空腹血清FFAs水平升高 。

Objective To investigate the relationship of fasting serum free fatty acids levels and insulin resistance in patients with metabolic syndrome.Methods The levels of fasting serum FFA were measured in 60 patients with MS and 20 healthy subjects by colorimetric assay.Comparison of levels of serum FFAs or ISI was done between two groups.The correlation analyses were also done between ISI and serum FFAs or any other characteristic parameter of MS.Results The levels of fasting serum FFAs in MS were(607.1±217.8)μmol/L,marked higher than those in normal controls( P <0.01);ISI in MS was 4.58±0.49,marked lower than that in normal controls( P <0.01).There was a markd negative correlation between ISI and serum FFAs( P <0.05, r =-0.329);also a negative correlation between ISI and BMI.Conclusion The elevated levels of serum FFAs in patients with MS reflected the degree of IR indirectly. \[