IMA、BNP和hsCRP在急性冠状动脉综合征早期诊断中的应用

Application of IMA,BNP and hs CRP in the diagnosis of early acute coronary syndromes

目的探讨缺血修饰白蛋白(IMA)、B型尿钠肽(BNP)、超敏C反应蛋白(hs CRP)在急性冠脉综合征(ACS)早期诊断中的作用。方法来自青岛市立医院96例ACS患者作为治疗组,其中急性心肌梗死(AMI)42例,不稳定型心绞痛(UAP)54例,分别于胸痛发作2、4、6、12、18及24 h抽血,另选50名健康体检者作为对照组,两组均检测其IMA、BNP、hs CRP含量,评价这三项指标在ACS早期的应用价值。结果在急性冠状动脉综合征患者中IMA水平于胸痛发作2 h已明显增高,4 h仍持续增高,明显高于正常对照组(P<0.05),6 h降至正常。BNP、hs CRP水平于胸痛发作2 h显著升高,于12 h达到峰值。结论 IMA、BNP、hs CRP的表达与ACS密切相关,在ACS早期诊断中具有很高的应用价值。

Objective To investigate the application of ischemia modified albumin(IMA),B-type natriuretic peptide and hypersensitive C-reactive protein in early diagnosis of acute coronary syndromes(ACS),Methods The 96 cases of ACS from Qingdao Municipal hospital,including 42 cases of acute myocardial infarction(AMI),54 cases of unstable angina pectoris(UAP),Then their blood samples were collected at 2,4,6,12,18 and 24 h after chest pain episode,50 healthy volunteers were as control;Detection of the content of IMA,BNP and hs CRP was done to give reasonable suggestions on the early diagnosis of ACS about them,Results At 2 hours after the onset of chest pain in patients with ACS,the level of IMA significantly increased;At 4 hours,it still increased and was significantly higher than that in control group until downing to normal at 6 hours,The BNP and hs CRP significantly increased at 2 hours,at 12 hours to reach peak,Conclusion The expression of IMA,BNP and hs CRP is closely related to ACS,It also has very high application value in the diagnosis of early ACS.