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乳腺癌原发灶间质纤维化与免疫微环境及预后的关系 被引量:2

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摘要 在乳腺癌的发生发展和转移过程中,肿瘤细胞与肿瘤微环境内的成纤维细胞、细胞外基质纤维结构和免疫细胞的相互作用至关重要,也成了近年来研究的热点[1]。肿瘤的细胞外基质纤维结构与正常组织相比明显增多,其成分以胶原蛋白为主,此外还包括纤维连接蛋白、蛋白聚糖、层粘连蛋白等[2]。肿瘤基质纤维结构能够抑制T细胞向肿瘤间质及癌巢的浸润[3],并且抑制治疗药物向肿瘤内渗透[2]。本研究中,
出处 《实用医药杂志》 2015年第2期148-150,共3页 Practical Journal of Medicine & Pharmacy
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  • 1Salmon, Hélène,Franciszkiewicz, Katarzyna,Damotte, Diane,Dieu-Nosjean, Marie-Caroline,Validire, Pierre,Trautmann, Alain,Mami-Chouaib, Fathia,Donnadieu, Emmanuel.Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors[J]. EN . 2012 (3)
  • 2Peter Simsa,Jean-Luc Teillaud,David I. Stott,József Tóth,Beatrix Kotlan.Tumor-infiltrating B cell immunoglobulin variable region gene usage in invasive ductal breast carcinoma[J]. Pathology & Oncology Research . 2005 (2)
  • 3Choi IK,Strauss R,Richter M,et al.Strategies to increase drug penetration in solid tumors. Front Oncol . 2013
  • 4Hyung-Ok Lee,Stefanie R Mullins,Janusz Franco-Barraza,Matthildi Valianou,Edna Cukierman,Jonathan D Cheng.FAP-overexpressing fibroblasts produce an extracellular matrix that enhances invasive velocity and directionality of pancreatic cancer cells. BMC Cancer . 2011
  • 5Loeffler Markus,Krüger J?rg A,Niethammer Andreas G,Reisfeld Ralph A.Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. The Journal of Clinical Investigation . 2006
  • 6Heldin Carl-Henrik,Rubin Kristofer,Pietras Kristian,Ostman Arne.High interstitial fluid pressure - an obstacle in cancer therapy. Nature reviews. Cancer . 2004
  • 7Reisfeld Ralph A.The Tumor Microenvironment: A Target for Combination therapy of Breast Cancer. Critical reviews in oncogenesis . 2012
  • 8JA Coronella,C Spier,M Welch,KT Trevor,AT Stopeck,H Villar.Antigen-driven oligoclonal expansion of tumor-infiltrating B cells in infiltrating ductal carcinoma of the breast. J Immunol . 2002

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