期刊文献+

雄激素受体基因微卫星CAG多态性与男性不育

The polymorphism of CAG Trinucleotide Repeats in the Androgen and Male Infertility
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摘要 不孕不育已成为困扰全世界许多育龄夫妇的一个重要问题.在不孕不育原因中,男性约占40%,女性约占40%,双方约占10%~20%,但仍有10%~15%原因不明.
出处 《中国计划生育学杂志》 2003年第7期447-448,共2页 Chinese Journal of Family Planning
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  • 1王钢,陈光椿,王晓慧,钟纪根,卢建.中国男性雄激素受体基因(CAG)n重复多态性的初步研究[J].中华医学遗传学杂志,2001,18(6):456-458. 被引量:19
  • 2Carlsen E, Giwercman A, Keiding N, et al. Evidence for decreasing quality of semen during past 50 years. BMJ, 1992,305 (6854.) :609 -613.
  • 3Krausy C, Quintana -Murci L, Mc Elreavy K. Prognostic value of Y deletion analysis. Hum Reprod,2000,15(7) :1431 - 1434.
  • 4Oates RD, Silber S, Brown LG,et al. Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome,and of 18 children conceived via ICSI. Hum Reprod,2002.17( 11 ):2813 -2824.
  • 5Quigley CA,De Bellis A, Marschke KB,et al. Androgen receptor defects: historical, clinical, and molecular perspectives. Endocr Rev,1995.16(3):271 -321.
  • 6Watkins WS, Bamshad M,Jorde LB. Population genetics of trinucleotide repeat polymorphisms. Hum Mol Genet, 1995,4(9) :1485 - 1491.
  • 7Chamberlain NL,Driver ED,Miesfeld RL. Tthe length and locatice of CAG trinuclectide repeats in the androgen receptor N - terminal domain affect transactivatice function. Nucleic Acids lies, 1994,22(15) :3181-3186.
  • 8Tut TG,Ghadessy FJ,Trifiro MA,et al. Long polyglutsmine tracts in the androgen receptor are associated with reduced trans - activation, impaired sperm production, and male infertility. J Clin Endocrinol Metab,1997.82( 11 ) :3777 - 3782.
  • 9Dowsing AT, Yong EL, Clark M, et al. Linkage between male infertility and trinucleotide repeat expansion in the androgen - receptor gene. Lancet, 1999,354(9179) :640 -643.
  • 10Kukuvitis A, Georgiou I, Bouba I, et al. Association of oestrogen receptor alpha polymorphisms and androgen receptor CAG trinucleotide repeats with male infertility:a study in 109 Greek infertile men. Int J Androl,2002,25(3) :149 - 152.

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