黄芪注射液对病毒性心肌炎患者血清胶原前肽的影响

Effect of austagalus membranaceus injection on serum procollagen pept ides in patients with viral myocarditis

目的研究黄芪注射液对心肌炎患者心脏胶原代谢的影响。方法83例临床心肌炎患者与20例健康志愿者作为研究对象,心肌炎患者予黄芪注射液治疗2周,在治疗前、后以ELISA法分别检查其血清中I型胶原羧基末端肘(ICTP)和Ⅲ型前胶原氨基末端肽(PⅢNP)浓度。健康志愿者不予用药作为空白对照。结果心肌炎患者血清胶原前肽水平较健康志愿者明显增高。经连续2周黄芪注射液治疗后,心肌炎患者ICTP和PIIINP血清浓度均下降,其中ICTP接近正常水平。结论黄芪注射液治疗心肌炎疗效可靠,黄芪注射液可能通过干预胶原代谢,抑制胶原过度增生而改善患者预后,减少并发症的发生。

Objective To study the effect of Austagalus membranaceus injection on cardiac collagen metabolism in patients with myocarditis. Methods 83 patient s with viral myocarditis and 20 healthy volunteers were enrolled. The former wer e treated with Austagalus membranaceus injection daily for 2 weeks. Before and a fter treatment, serum concentrations of procollagen type I carboxyterminal pepti de(ICIP) and procollagen type Ⅲaminoterminal peptide (PIIINP) were detected by Enzyme Linked Immunosorbent Assay(ELISA). The volunteers were not treated and se rved as controls. Results Serum procollagen petides concentrations were signific antly increased in patients with viral myocarditis compared with volunteers. Aft er 2 weeks of treatment, both ICTP and PIIINP were decreased. Conclusions Austag alus membranaceus injection was effective for treatment of viral myocarditis and may inhigit collagen metabolism and improve prognosis.