肾移植术后重症社区获得性肺炎合并纵隔气肿临床分析(附9例报道)

Clinical analysis of severe community-acquired pneumonia complicated with mediastinal emphysema after renal transplantation(report of 9 cases)

目的探讨肾移植术后重症社区获得性肺炎(CAP)合并纵隔气肿的临床治疗和转归。方法回顾性分析9例肾移植术后重症CAP合并纵隔气肿患者的临床资料。记录患者入重症监护室(ICU)时的急性生理学及慢性健康状况评分Ⅱ(APACHEⅡ)及氧合指数。观察患者的纵隔气肿合并症情况及相应的处理,记录患者在ICU期间的治疗经过、ICU病死率、ICU住院时间、总住院时间。所有患者行病原学检查。结果 9例肾移植术后重症CAP合并纵隔气肿患者的APACHEⅡ评分为14(8～21)分,氧合指数为150(133～189)mmHg。9例患者中,单纯细菌感染3例;细菌感染合并病毒感染3例;结核分枝杆菌合并其他细菌感染1例;病毒感染1例;1例患者未找到病原学证据。纵隔气肿并发皮下气肿7例,并发气胸6例。治疗方式包括抗感染,调整免疫抑制方案,纵隔引流、胸腔闭式引流、皮下切开及体外膜肺氧合(ECMO)治疗。6例患者行有创正压通气(IMV),2例行无创正压通气(NIV),1例经鼻高流量吸氧(HFNC)。9例患者中,ICU病死率为6/9,其余3例患者均恢复出院,ICU住院时间26(17～40)d,总住院时间27～61 d。结论纵隔气肿是肾移植术后重症CAP的严重并发症,病死率高。对此类患者应加强影像学评估、及时引流、充分镇静,必要时行ECMO治疗。

Objective To investigate the clinical treatment and outcomes of severe community-acquired pneumonia(CAP) complicated with mediastinal emphysema after renal transplantation. Methods Clinical data of9 patients with severe CAP complicated with mediastinal emphysema after renal transplantation were retrospectively analyzed. The acute physiology and chronic health evaluation Ⅱ(APACHEⅡ) and oxygenation index were recorded when the patients were admitted to the intensive care unit(ICU). The complications of mediastinal emphysema and corresponding treatment were observed. The treatment course during the ICU, mortality rate in ICU, ICU stay time and hospital stay time were recorded. All patients underwent pathogenic examinations. Results The APACHE Ⅱ score of9 patients with severe CAP complicated with mediastinal emphysema after renal transplantation was 14(8-21) scores and the oxygenation index was 150(133-189) mmHg. Among 9 patients, 3 cases were infected by bacteria alone, 3 cases were infected by bacterial infection combined with viral infection, 1 case was infected by mycobacterium tuberculosis complicated with other bacterial infection and 1 case was viral infection. No pathogenic evidence was detected in the remaining 1 patient. Mediastinal emphysema complicated with subcutaneous emphysema occurred in 7 cases and pneumothorax occurred in 6 cases. Treatment methods included anti-infection, modified immunosuppressive program,mediastinal drainage, thoracic closed drainage, subcutaneous incision and extracorporeal membrane oxygenation(ECMO)treatment. Six patients received invasive mechanical ventilation(IMV), 2 received non-invasive positive pressure ventilation(NIV) and 1 received high-?ow nasal oxygen cannula(HFNC). Among 9 patients, the mortality rate in ICU was 6/9, the remaining 3 patients were recovered and discharged, the ICU stay time was 26(17-40) d, and the total hospital stay time was 27-61 d. Conclusions Mediastinal emphysema is a serious complication of patients presenting with severe CAP after renal transplantation with a high mortality rate. For these patients, imaging evaluation, timely drainage and full sedation should be strengthened, and ECMO treatment should be delivered when necessary.