PMBP缩氨基酚的合成、晶体结构及抑菌活性

Synthesis, Crystal Structure and Bacteriostatic Activities of Compounds Derived from PMBP and Aminophenol

利用1-苯基-3-甲基-4-苯甲酰基-5-吡唑啉酮(PMBP)与邻、间、对氨基酚合成了三种PMBP缩氨基酚Schiff碱,并进行了结构表征.PMBP缩邻氨基酚的X射线衍射分析测定结果表明,该缩合反应是通过质子转移形式,形成了烯胺酮式结构.抑菌活性测定结果表明它们对革兰氏阳性金黄色葡萄球菌和革兰氏阴性大肠杆菌均有较强的抑制作用.

Three new compounds derived from 1-phenyl-3-methyl-4-benzoyl-pyrazolin-5-one with o-aminophenol (A), m-aminophenol (B) and p-anunophenol (C) have been synthesized. Their structures are characterized by IR, UV and H-1 NMR. X-ray structure determination of the compound A shows that it is a neutral tridentate ligand in enamineketo form. The bacteriostatic activities of the three compounds have been determined by paper disc method. The tests indicated that they have good bacteriostatic activities against Escherichia cock and Staphyococcus aureus. It provides basis for the determination of the antibacterial activity of their complexes.