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趋化因子与肝病的研究进展 被引量：3

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摘要 近年来,趋化因子(Chemokines)在肝病发病机制中的作用越来越受到重视.大量研究表明,趋化因子在各种肝损伤中表达上调.通过应用趋化因子抑制剂,特异性趋化因子缺陷动物模型以及调控趋化因子受体等方法,趋化因子与炎症细胞浸润的密切关系得以证实.而在肝脏慢性炎症中,炎症因子、生长因子、氧应激及其产物等刺激因素促进趋化因子的表达.高表达的趋化因子能激活肝星状细胞(HSC)参与肝纤维化甚至肝硬化的形成.由于趋化因子有促进血管生成和新生物增生的作用,其与肿瘤的关系也成为研究的热点.本文将阐述趋化因子在酒精性肝病,肝纤维化,肝硬化和肝癌中的作用机制.
作者 胡迎宾 田德安 刘南植
机构地区 华中科技大学同济医学院附属同济医院消化内科
出处 《世界华人消化杂志》 CAS 2003年第7期1040-1042,共3页 World Chinese Journal of Digestology
关键词 趋化因子 肝病 发病机制 趋化因子受体 肝纤维化 肝星状细胞
分类号 R575 [医药卫生—消化系统]
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参考文献20

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同被引文献24

  • 1陈辉扬,陈军,温平康.茵栀黄注射液的药理作用与临床应用评价[J].药品评价,2005,2(2):122-124. 被引量：27
  • 2伏建峰,史清海,路西春,岳新华,张东辉.大鼠慢性酒精诱导肝损伤中肝细胞凋亡与Fas表达[J].西北国防医学杂志,2006,27(5):362-364. 被引量：3
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  • 10金哲洙.肝细胞生长因子与肝损伤关系研究进展[J].延边大学医学学报,2007,30(4):307-309. 被引量：1

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世界华人消化杂志
2003年 第7期

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