胰岛素治疗对糖尿病性大鼠阴茎勃起功能的影响

EFFECTS OF TREATMENT WITH INSULIN ON THE ERECTILE FUNCTION IN DIABE-TIC RATS

目的 :探讨糖尿病对大鼠勃起功能的影响及胰岛素治疗对糖尿病性大鼠阴茎勃起功能障碍的效果。方法 :将雄性 SD大鼠腹腔内注射链脲佐菌素 (STZ)制造糖尿病动物模型 ,用胰岛素对糖尿病大鼠进行干预治疗 8周和 1 6周后 ,观察各组大鼠注射阿朴吗啡后的阴茎勃起情况并评价其勃起功能。结果 :与健康对照组相比 ,糖尿病未治疗组阴茎勃起次数明显降低。8周时胰岛素治疗组平均勃起次数明显高于糖尿病未治疗组 (P<0 .0 1 ) ,但较健康对照组低 (P<0 .0 1 )。1 6周时 ,胰岛素治疗组的平均勃起次数亦较糖尿病未治疗组高 ,但差异无统计学意义 (P>0 .0 5 )。结论 :糖尿病严重影响阴茎勃起功能 。

Objective:To study the effects of diabetes on the erectile function in rats and whether the function of penile erection in diabetic rats was improved by the treatments of insulin.Methods:Male Sprague Dewley rats were injected intraperitoneally with streptozotozin(STZ) to make experimental models of diabetes mellitus(DM).Diabetic rats were treated with insulin for 8 or 16 weeks,then injected with apomorphine in all of the rats,penile erections were observed in order to evaluate their erectile function.Result:Compared with the controls(C group), penile erectile times in the DM rats(D group) decreased significantly(P<0 01).And in the 8th week,the above indexe in the diabetic rats treated with insulin(DI group) were significantly higher than those in D group(P<0 01),whereas lower than those in C group(P<0 01). The erectile function of the rats in the DI group were higher unsignificantly than those in D group in the 16th week(P>0 05).Conclusion:Penile erection was seriously impaired in rats with DM,and the function of penile erection in diabetic rats was improved by the treatments of insulin.