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风疹易感人群婚前风疹疫苗接种预防先天性风疹综合征 被引量:5

Analyzing the efficiency of the vaccine in preventing these fetus of the pregmant women from congenital rubella syndrome
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摘要 目的 :探讨婚前风疹易感人群风疹疫苗接种在提高孕妇对风疹的免疫力 ,预防先天性风疹综合征中的作用。方法 :对 10 913例婚前风疹病毒抗体IgG阴性者给予国产风疹减毒活疫苗注射。 3个月随防 6 71例 ,比较风疹疫苗接种前后该地区孕妇近期风疹感染的发病率。结果 :818例风疹病毒抗体IgG阴性者接种后抗体转阳率为 99 8%。风疹疫苗接种前后 3年孕妇近期风疹感染率分别为 0 37%及 0 0 8% ,有明显下降 ,有非常显著差异 (P <0 0 0 1)。结论 :应用国产风疹减毒活疫苗对婚前易感人群作预防接种可提高育龄妇女对风疹的免疫力 ,降低孕期风疹感染的发生率 ,是预防先天性风疹综合征及风疹致畸的有效。 Objective:To assess the immune status of a group of pregnant women who had been immunized before married At the same time,to detect the efficiency of the vaccine in preventing these,fetus of the pregnant women from congenital rubella syndrome.Methods:IgG rubella antibodies were assessed by ELISA method in about 10 913 premarital people.The women with IgG negative were injected rubella attenuated living vaccine.After three-months,the IgG was assessed again in the 671 immunized women.Then analyzing the difference of incidence rate in not immunized gravidas and immunized one at the area.Results:Before immunized,the premaral women's IgG positive rate was 7.8%,After immunized,the women's IgG positive rate was 99.8%.Rubella infection rate in not immunized pregnant women and immunized one were 0.37% and 0.08% respectively.The difference was significant (P<0.001).Condusion:By inoculating rubella attenuated living vaccine which made in china to the premarital people were susceptible to rubella virus,the women's immune status to rubella virus was improved.The pregnant women's incidence rates were reduced.The method was efficient and safe in preventing these fetus of the pregnant women from congenital rubella syndrome.
出处 《广州医药》 2003年第4期1-2,共2页 Guangzhou Medical Journal
关键词 风疹易感人群 风疹疫苗 预防接种 先天性风疹综合征 Rubella Rubella virus vaccine Preventive inoculation Congenital rubella syndrome
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参考文献7

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二级参考文献8

  • 1李性善,中国公共卫生杂志,1991年,7卷,339页
  • 2韩秀娟,山东大学学报,1990年,10卷,124页
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  • 4戴斌,中华妇产科杂志,1986年,21卷,5页
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