奥沙利铂和多西他赛联合替吉奥与奥沙利铂联合替吉奥治疗晚期复发性胃癌的临床效果

Efficacy of DSOX and SOX Regimen in The Treatment of Advanced Recurrent Gastric Cancer

目的分析晚期复发性胃癌通过奥沙利铂、多西他赛联合替吉奥(DSOX)与奥沙利铂联合替吉奥(SOX)两种方案治疗的效果。方法选取2016年1月—2017年1月济南市长清区人民医院收治的晚期复发性胃癌患者64例,将患者分为试验组和常规组,每组32例。常规组患者通过SOX治疗,试验组通过DSOX治疗,比较两组的治疗综合情况。结果常规组患者QOL评分为(68.8±2.9)分,低于试验组的(88.8±3.6)分,差异有统计学意义(P<0.05)。常规组总有效率(90.63%)低于试验组(68.75%),差异有统计学意义(P<0.05)。试验组不良反应发生率为18.75%,常规组不良反应发生率为28.13%,试验组低于常规组,差异有统计学意义(P<0.05)。结论晚期复发性胃癌患者通过DSOX治疗,效果显著,能有效提升患者的生活质量,同时降低患者不良反应发生率。

Objective To analyze the efficacy of DSOX and SOX in the treatment of advanced recurrent gastric cancer.Methods Sixty-four patients with advanced recurrent gastric cancer admitted to Changqing District People’s Hospital of Jinan City from January 2016 to January 2017 were selected.The patients were divided into experimental group and routine group,32 cases in each group.Patients in routine group were treated with SOX(oxaliplatin and teggio).The experimental group was treated with DSOX(oxaliplatin,docetaxel and tegueo).Results The QOL score of the routine group was(68.8±2.9),lower than that of the experimental group(88.8±3.6),and the difference was statistically significant(P<0.05).The total effective rate of routine group(90.63%)was lower than that of experimental group(68.75%),and the difference was statistically significant(P<0.05).The adverse reaction rate was 18.75%in the experimental group,28.13%in the routine group,and significantly lower in the experimental group than in the routine group(P<0.05).Conclusion The treatment of advanced recurrent gastric cancer by DSOX is effective in improving the quality of life and reducing the rate of adverse reactions.