乳腺癌患者血清糖类抗原153、E-钙黏蛋白、表皮生长因子受体水平检测的临床意义

Clinical significance of detection of serum CA153, E-cad and EGFR levels in patients with breast cancer

目的探究乳腺癌患者血清糖类抗原153(CA153)、E-钙黏蛋白(E-cad)、表皮生长因子受体(EGFR)水平检测的临床意义。方法回顾性分析黄冈市中心医院168例乳腺癌患者临床资料(乳腺癌组),并收集154例行手术治疗的乳腺良性肿瘤患者临床资料(乳腺良性肿瘤组)及152例健康体检者相关资料(健康对照组)。比较3组血清CA153、E-cad、EGFR水平有无差异,利用受试者工作特征(ROC)曲线评估血清CA153、E-cad、EGFR诊断乳腺癌的应用价值;并分析乳腺癌临床病理特征与血清CA153、E-cad、EGFR表达水平的关系。结果乳腺癌组血清CA153、E-cad、EGFR水平高于乳腺良性肿瘤组、健康对照组(P<0.05),且乳腺良性肿瘤组血清CA153、E-cad、EGFR水平高于健康对照组(P<0.05)。ROC曲线结果显示,血清CA153、E-cad、EGFR对乳腺癌均具有较高的诊断效能。TNM分期较高、组织学分级较高及伴淋巴结转移的乳腺癌患者血清CA153、E-cad、EGFR水平高于TNM分期较低、组织学分级较低和无淋巴结转移者(P<0.05)。结论血清CA153、E-cad、EGFR的检测在乳腺癌诊断及临床病理特征评估中有重要作用,于临床乳腺癌诊疗工作有利。

Objective To explore the clinical significance of detection of serum cancer antigen 153(CA153),E-cadherin(E-cad)and epidermal growth factor receptor(EGFR)levels in patients with breast cancer.Methods The clinical data of 168 patients with breast cancer in Huanggang Central Hospital were retrospectively analyzed(breast cancer group).The clinical data of 154 patients with benign breast tumor who underwent surgery(benign breast tumor group)and the related data of 152 healthy subjects for physical examination(healthy control group)were collected.The differences of serum CA153,E-cad and EGFR levels were compared among the three groups.The receiver operating characteristic curve(ROC curve)was used to evaluate the application value of serum CA153,E-cad and EGFR in the diagnosis of breast cancer.The relationship between clinicopathological features of breast cancer and serum expression levels of CA153,E-cad and EGFR was analyzed.Results The levels of serum CA153,E-cad and EGFR in breast cancer group were significantly higher than those in benign breast tumor group and healthy control group(P<0.05),and the levels of serum CA153,E-cad and EGFR in benign breast tumor group were higher than those in healthy control group(P<0.05).ROC curve results showed that serum CA153,E-cad and EGFR were found to have high diagnostic efficacy for breast cancer.The levels of serum CA153,E-cad and EGFR in breast cancer patients with high TNM stage,high histological grade and lymph node metastasis were higher than those of patients with low TNM stage,low histological grade and no lymph node metastasis(P<0.05).Conclusions The detection of serum CA153,E-cad and EGFR plays an important role in the diagnosis and clinical pathological evaluation of breast cancer,and it is beneficial to the diagnosis and treatment of breast cancer.