二甲双胍治疗多囊卵巢综合征的价值分析

Clinical Effect of Metformin in the Treatment of Polycystic Ovary Syndrome

目的探讨二甲双胍治疗多囊卵巢综合征的临床应用价值。方法选取2015年6月—2016年6月本院收治的40例多囊卵巢综合征患者,随机将其分为对照组和观察组,各20例。对照组给予炔雌醇环丙孕酮片治疗,观察组给予炔雌醇环丙孕酮片和二甲双胍治疗,观察两组临床治疗效果。结果治疗后,观察组雌激素高于对照组,睾酮、促卵泡生成素、促黄体生成素、胰岛素抵抗指数低于对照组(P<0.05)。观察组治疗总有效率为85.0%(17/20),高于对照组的60.0%(12/20)(P<0.05)。两组患者在用药期间均未出现任何不良反应。结论二甲双胍治疗多囊卵巢综合征有显著的临床效果,可以提高性激素水平,同时也可以改善胰岛素水平,推荐临床应用。

Objective To analyze the clinical value of metformin in the treatment of polycystic ovary syndrome(PCOS).Methods 40 cases of PCOS in our hospital from June 2015 to June 2016 were selected,and the patients were randomly divided into the control group and observation group,each of 20 cases.The control group was given the treatment of ethinylestradiol and cyproterone acetate tablets.The observation group was given ethinylestradiol and cyproterone acetate tablets and metformin.The clinical therapeutic effects of the two groups were observed.Results After treatment,the estrogen of observation group was higher than that in control group,and testosterone,follicle stimulating hormone,luteinizing hormone and insulin resistance index of observation group was lower than those in control group(P<0.05).The total efficacy rate of observation group was 85.0%(17/20),higher than that in control group of 60.0%(12/20)(P<0.05).There were no adverse reactions in the two groups during the medication period.Conclusion Metformin has a significant clinical effect in the treatment of polycystic ovary syndrome.It can improve the level of sex hormone and insulin.Therefore,it is recommended for clinical application.