肾康胶囊对急性肾小球肾炎治疗作用的临床研究

Clinical study of therapeutic effect of Shenkang capsule in treatment of acute glomerulonephritis

目的 :观察自行组方研制的肾康胶囊治疗急性肾小球肾炎的临床疗效。方法 :将 38例肾病专科门诊急性肾小球肾炎患者随机分两组 ,对照组给予青霉素 80× 10 4 U肌肉注射 ,每日 2次 ,连用 2周 ;有水肿、高血压者给予利尿、降压等对症治疗。肾康胶囊组在青霉素、对症治疗基础上加服肾康胶囊 (由茯苓、泽泻、茅根、蝼蛄、鳖甲、肾炎草、生大黄等组成 ) ,每次 5粒 ,每日 3次。两组疗程均为 2周 ,疗程结束后观察两组患者用药前后的体质量、平均动脉压、2 4 h尿蛋白定量、1h尿红细胞排泄率、血尿素氮、血清肌酐、钾和钠的变化 ;2 4 h尿蛋白定量及 1h尿红细胞排泄率随访 6周。结果 :肾康胶囊能显著减轻急性肾小球肾炎患者 2 4 h尿蛋白定量〔用药 2周后由 (2 6 7± 16 2 ) m g/ 2 4 h降到 (14 8± 110 ) mg/ 2 4 h,P<0 .0 5〕及 1h尿红细胞排泄率〔用药 2周后由(46± 7)× 10 4 / h降到 (11± 6 )× 10 4 / h,P<0 .0 5 ;用药 6周肾康胶囊组 (5± 3)× 10 4 / h,对照组 (13± 8)× 10 4 / h,P<0 .0 5〕。且使用过程中无不良反应。结论

Objective: To observe the clinical effect of Shenkang capsule (SKC) for treating acute glomerulonephritis(AGN). Methods: SKC was prepared by modern pharmacy technique with Chinese herbs of poria, alisma, rhizoma imperatae, gryllotulpa africana, carapax trionycis, nephritis herb and raw rhubarb. Thirty-eight cases with AGN were divided into the control group(18 cases) and the SKC group(20 cases) randomly. Patients in the control group were treated with penicillin G 80×10 4 U by muscle injection, two times every day for two weeks, and patients accompanied edema and hypertension symptom were treated to symptom. Patients in the SKC group were treated with SKC, 5 tables each time, three times every day on the base of treatment of penicillin and to symptom . The courses in two groups were all two weeks. At the end of the treatment, the weight, mean arterial pressure, 24 hours urine protein quantity, 1 hour urine red blood cell excreting rate(1huRBCer), blood urea nitrogen, serum creatinine, potassium and sodium before and after the treatment were observed, and 24 hours urine protein quantity and 1huRBCer were observed for six weeks followed the treatment. Results : SKC could significantly lighten 24 hours protein urine quantity 〔reduced from (267±162)mg/24 h to (148±110) mg/24 h two weeks after giving SKC, P <0 05〕 and significantly reduce 1huRBCer 〔reduced from (46±7)×10 4/h to (11±6)×10 4/h two weeks after giving SKC, P <0 05; (5±3)×10 4/h in SKC group six weeks after giving SKC and (13±8)×10 4/h in control group, P <0 05〕 for AGN. There was no side-effect in the course of using SKC. Conclusion: AGN could be treated with SKC for preventing its delay.