中西医结合治疗SARS临床研究

Clinical study on treatment of severe acute respiratory syndrome with integrated traditional Chinese and western medicine

目的 :评价中西医结合方法治疗严重急性呼吸综合征 (SARS)的临床疗效。方法 :将 2 8例 SARS住院患者随机分为中西医结合方法治疗组和单纯西医方法对照组 ,每组各 14例。两组均予抗 SARS西医常规治疗 ,如抗病毒、糖皮质激素、免疫增强剂、无创呼吸机等。治疗组在中医辨证的基础上用生物场效应仪进行药物筛选并给予治疗 ,如穿琥宁注射液、参麦注射液、护肺清痧饮 ,解毒止痛胶囊、逐饮散结胶囊、清痧灵喷剂等。结果 :治疗组体温下降至正常、症状恢复、X线胸片阴影吸收、血氧饱和度恢复等时间均优于对照组 ,但无统计学差异(P均 >0 .0 5 ) ;治疗组激素用量平均 (6 99.2 9± 111.6 6 ) mg,显著低于对照组平均 (12 5 7.14± 2 4 7.90 ) mg(P<0 .0 1)。结论 :中西医结合疗法治疗 SARS能显著减少激素用量 ,并减少并发症的发生。

Objective: To evaluate the effect of integrated traditional Chinese and western medicine treatment on severe acute respiratory syndrome(SARS). Methods: Twenty-eight SARS cases were randomly divided into treatment group (using integrated traditional Chinese and western medicine therapy) and control group (purely using western medicine), 14 cases for each group. Both groups were given routine anti-SARS of western medicine, i. e . antivirotics, corticosteroids, immunomodulation agent and non-invasive ventilation . The treatment group was treated with the Chinese herbs on the basis of traditional Chinese medicine differentiation, i.e. Chuanhuning injection, Shenmai injection, Hufei Qingsha drink, Jiedu Zhitong capsule, Zhuyin Sanjie capsule, Qingshaling spray . Results: After treatment the time of decreasing of temperature, improvement of symptoms, absorption of chest X-ray, recovery of degree of blood oxygen saturation in treatment group were better than those in control group, but they had no discrepancy significantly (all P >0 05). The dosage of glucocorticoid in treatment group was less than that in control group〔(699 29±111 66)mg vs. (1 257 14±247 90)mg, P <0 01〕. Conclusion: It is showed that the integrated traditional Chinese and western medicine treatment can significantly decrease the dosage of glucocorticoid and the incidence of complications.