良性前列腺增生和前列腺癌组织中雄激素受体的表达

The expression of androgen receptor gene in benign prostatic hyperplasia and prostatic cancer tissues

目的 探讨雄激素受体 (AR)与良性前列腺增生 (BPH)和前列腺癌 (PCa)的关系。 方法 应用免疫组织化学技术检测 4 0例BPH、4 0例PCa患者及 2 0例正常前列腺组织 (正常对照组 )AR的表达。 结果 BPH组、PCa组、正常对照组AR表达的阳性率分别为 98%、5 3%、75 % ,相互比较差异均有显著性 (P <0 0 5 )。高分化癌、中分化癌、低分化癌的AR表达的阳性率分别为 6 7%、5 6 %、30 % ,高、中分化癌的AR表达的阳性率比低分化癌高 (P <0 0 5 )。早期前列腺癌的AR表达阳性率 (6 9% )比晚期前列腺癌 (4 2 % )高 (P <0 0 5 )。 结论 BPH组织中AR的表达高于正常前列腺组织 ,AR在BPH的发生、发展中起着重要作用 ;PCa组织中AR的表达低于正常前列腺组织。AR的表达与肿瘤分级、分期相关。

Objective To study the expression of androgen receptor(AR) gene in benign prostatic hyperplasia(BPH) and prostatic cancer(PCa) tissues and to evaluate its clinical significance. Methods The expressions of AR gene in tissues of 40 BPH patients, 40 PCa patients and 20 normal people were examined with immunohistochemical methods. Results The positive staining rates of AR in patients with BPH, PCa and in controls were 98%, 53% and 75%, respectively(P<0.05 between grouops). The AR expression was significantly higher in well(67%)or moderately(56%) differentiated adenocarcinoma than that in poorly differentiated tumors(30%)(P<0.05), and higher in tumors at early stage(69%)than those in advanced stage(42%)(P<0.05). Conclusions The positive expression rate of AR in BPH tissue was higher than that in normal prostatic tissue. AR may play an important role in the development, growth and progression of BPH. AR expression was lower in PCa tissue than that in normal prostatic tissue. There were correlations between AR expression and tumor grades or tumor stages.