替吉奥与顺铂对晚期胃癌治疗疗效的观察与对比

Clinical efficacy of the combination of Gio and cisplatin for treatment of advanced gastric cancer

目的研究探讨联合应用替吉奥与顺铂对晚期胃癌进行治疗的临床疗效。方法选取来我院就诊的晚期胃癌患者82例,根据使用治疗药物的不同随机分为观察组和对照组,每组各41例。对照组采用卡倍他滨片口服加用静脉注射顺铂,观察组采用替吉奥口服加用顺铂静脉注射。经过治疗后,观察患者治疗的临床疗效,生活质量的改善情况,以及治疗过程中不良反应的发生情况。结果观察组的临床获益率及有效率均显著优于对照组,P<0.05;观察组KPS评分要显著优于对照组,P<0.05;血小板减少及手足综合征的发生观察组要显著少于对照组,P<0.05;血红蛋白减少、口腔炎、肾功能损害在两组治疗组治疗中差异无统计学意义。结论联合应用替吉奥与顺铂对晚期胃癌进行治疗的临床疗效较好,取得了较高的有效率及临床获益率,并且发生不良反应的情况较少,使用比较安全,在临床治疗晚期胃癌时,该方案值得积极应用。

OBJECTIVE To evaluate the clinical efficacy of the combination of Gio and cisplatin for treatment of advanced gastric cancer.82 cases of patients with advanced gastric cancer.METHODS To our hospital,according to the use of different drugs were randomized:41cases in the observation group,41 cases in the control group,the control group used the card fold tablet gemcitabine plus cisplatin intravenously observed Gio group with oral plus intravenous cisplatin.After treatment,the clinical observation of patients,improvement in quality of life,as well as the course of treatment the incidence of adverse reactions.The results of clinical benefit rate and the effective observation group were significantly better than the control group,P<0.05;observation group KPS score was significantly better than the control group,P<0.05;thrombocytopenia and hand-foot syndrome occurred in the observation group was significantly less in the control group,P<0.05;hemoglobin decrease,stomatitis,renal dysfunction in two treatment groups was not statistically significant treatment differences.COUCLUSIONS The clinical efficacy of combination with cisplatin Gio treatment of advanced gastric cancer better achieved higher efficiency and clinical benefit rate,and with fewer adverse reactions,the use of relatively safe in clinical treatment of advanced when the cancer,should actively be applied.