肝动脉化疗栓塞术前、后静脉应用止吐药物的临床研究

Clinical Study on the Effects of Intravenous Antiemetics before or after Transcatheter Arterial Chemoembolization

目的 研究肝动脉化疗栓塞术前、后静脉应用止吐药物对术后消化道化疗反应的影响,为临床护士执行医嘱提供依据。方法 运用观察研究法,对106例接受肝动脉化疗栓塞治疗的患者进行随机分组,分别于肝动脉化疗栓塞术前、后30～60min内静脉应用止吐药物,分析比较术后消化道化疗反应程度及药物疗效。结果 两组患者术后3d内的消化道化疗反应程度无显著性差异(P>0.05);两组患者静脉应用同种及同剂量止吐药的有效性比较,仍无显著性差异(P>0.05)。结论 肝动脉化疗栓塞术前、后30～60min内静脉应用止吐药疗效无明显差异,但术后应用止吐药可防止各种不可控因素使患者不能按计划接受治疗造成的药物浪费和思想顾忌,且减少术前静脉穿刺给患者带来的痛苦。

Objective To compare the effects of intravenous antiemetics on digestive chemotherapy reactions before and after TACE in an attempt to establish guidelines for nurses in implementing medical orders. Methods 106 patients with hepatocellular carcinoma who underwent TACE were divided into two groups randomly. Antiemetics were administered intravenously 30 -60 minutes before or after TACE, and the degrees of digestive chemotherapy reactions and curative effects were compared and analyzed. Results There was no significant difference in the degree of digestive reactions at 3 days of post-operation between the two groups ( P >0.05). The antiemetic effects were not significantly different between the two groups with reference to the same drug at the same dose ( P >0. 05). Conclusion There was no significant difference in the clinical effect of intravenous use of the antiemetics 30 - 60 minutes before or after TACE, but use of antiemetics after TACE can avoid wasting drugs because of patients' refusal to use the drug due to uncontrolled factors and free patients of pain from venipuncture before TACE.