476对不良孕产史夫妇相关因素探讨

Study on the cause of undesirable obstetrc history in 476 cases

目的 探讨不良孕产史的原因 ,以对不良孕产史夫妇今后的生育进行指导。 方法 对曾在我院就诊的 4 76对有不良孕产史的夫妇进行职业调查 ,了解有害物质接触史情况 ,并行TORCH感染筛查、染色体分析、高危病例进行梅毒感染筛查及糖尿病筛查等。 结果 TORCH感染率 4 6 .2 % (2 2 0 / 4 76 ) ,染色体异常率 5 .7% (5 4 / 95 2 ) ,有害物质接触史占 12 .2 % (5 8/ 4 76 ) ,梅毒感染占被检者的 14 .3% (12 / 84 ) ;妊娠合并糖尿病占被检者的 5 2 .7% (2 9/ 5 5 )。 结论 TORCH感染、染色体异常、有害物质接触史是不良孕产史的主要原因 ,梅毒感染、妊娠合并糖尿病等也是不容忽视的因素。

Objectives To investigate the cause of undesirable previous pregnancy in families in order to give them the medical suggestion for subsequent pregnancy. Methods 476 couples were enrolled in this study in our hospital.Data collected including their occupation and history of exposure to toxic substance.Screening for TORCH infections,syphilis and diabetes mellitus as well as analysis for chromosome karyotypes were performed. Results 46.2 %(220/476)affected with TORCH infections,and the frequency of chromosomal abnormalities was 5.7 %(54/952).12.2 %(58/476) cases had the history of toxicant exposure.Cases with syphilitic infection were 14.3 %(12/84) and diabetes mellitus were 52.7 %(25/55) among examined subjects. Conclusion Our study showed that TORCH infections,chromosomal abnormalities and toxic exposure contributed to the poor previous pregnancy and syphilitic infection as well as diabetes mellitus also played a role in poor birth outcome.