急性重症安眠药中毒的急诊治疗及应用效果观察

Emergency treatment of acute severe sleeping pills poisoning and application efficacy observation

目的研究急性重症安眠药中毒的急诊治疗效果。方法根据随机数字表法将2016年9月—2017年8月本院接收的急性重症安眠药中毒患者72例分为对照组和观察组,每组各36例,对照组采取常规治疗,观察组加用血液灌流治疗。将两组急性重症安眠药中毒患者的抢救成功率、生理指标、恢复指标以及并发症发生情况进行比对。结果观察组急性重症安眠药中毒患者的抢救成功率(97.22%)高于对照组(83.33%)(P<0.05);观察组患者治疗后的舒张压、收缩压较治疗前明显升高,且高于对照组(处于正常范围内),心率、PaO_2均高于对照组,PaCO2低于对照组,差异具有统计学意义(P<0.05);观察组急性重症安眠药中毒患者的意识恢复时间、自主呼吸恢复时间以及住院时间均短于对照组,差异具有统计学意义(P<0.05);两组患者的并发症发生率进行比较,观察组(5.56%)比对照组(27.78%)更低(P<0.05)。结论在急性重症安眠药中毒患者急诊治疗中联合基础治疗和血液灌流治疗安全有效,有助于患者生理状态的改善,促进患者尽快恢复呼吸和意识,可减少并发症的发生。

Objective To study the effect of emergency treatment of acute severe sleeping pills poisoning.Methods According to the random number table method,72 patients with acute severe sleeping pills poisoning admitted to our hospital from September 2016 to August 2017 were divided into control group and observation group,36 cases in each group.The control group received routine treatment and the observation group was treated with blood perfusion method.The rescue success rate,physiological indicators,recovery indicators and complications of two groups of patients with acute severe sleeping pills were compared.Results The success rate of rescue in the observation group was 97.22%,which was higher than that in the control group( P< 0.05). The diastolic blood pressure and systolic blood pressure in the observation group were significantly higher than those before treatment,and significantly higher than those in the control group as well( in the normal range),heart rate and PaO2 were higher than the control group,PaCO2 was lower than the control group,P<0.05. The consciousness recovery time,spontaneous breathing recovery time and hospitalization time of the patients in the observation group were shorter than the control group,the difference was statistically significant( P < 0. 05). The incidence of complications was 5.56% in the observation group,which was lower than that in the control group( P < 0. 05).Conclusions Combination of basic therapy and hemoperfusion in the emergency treatment of patients with acute severe sleeping pills poisoning is safe and effective,which can improve the physiological state of patients,promote the recovery of breathing and consciousness as soon as possible,and reduce the occurrence of complications.