参附注射液对中老年慢性心力衰竭患者的疗效

Effect of Shenfu injection on middle-and old-aged patients with chronic heart failure

目的分析参附注射液对中老年慢性心力衰竭患者的治疗效果及其对患者血清中BNP、CRP及左心室射血分数水平的影响。方法选择2014年1月—2018年9月本院收治的76例慢性心力衰竭患者作为研究对象,随机数表法分为对照组和实验组两组,每组各38例。对照组患者根据指南给予标准治疗,实验组患者在标准治疗的基础上再额外增加参附注射液。比较两组的治疗效果及治疗前后患者血清中脑钠肽(BNP)、超敏C反应蛋白(CRP)水平变化情况组以及左心室射血分数变化情况。结果治疗前两组患者血清中的BNP和CRP水平差异无统计学意义(P>0.05);治疗后水平较治疗前显著降低(P<0.05),且实验组水平显著低于对照组(P<0.05)。实验组中老年慢性心力衰竭患者的治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组左心室射血分数差异无统计学意义(P>0.05);治疗后,两组左心室射血分数明显提高,且实验组明显高于对照组,差异均有统计学意义(P<0.05)。结论在中老年心力衰竭患者给予常规治疗的基础上联合参附注射液,能够改善治疗效果,保护心肌功能,值得临床应用。

Objective To analyze the therapeutic effects of Shenfu injection on middle-and old-aged patients with heart failure,and its influence on the concentration of BNP and CRP and left ventricular ejection fraction.Methods 76 patients with chronic heart failure,those were admitted to our hospital during January 2014 and September 2018,were randomlydivided into control group and observation group,38 cases in each group.The patients in control group received standard therapy according to treatment guide,while thepatients in observation received Shenfu injection combined standard therapy.The changes of serum brain natriuretic peptide(BNP),hypersensitive C-reactive protein(CRP)levels,the levels of left ventricular ejection fraction(LVEF),and therapeutic effects were compared.Results The differences of the levels of serum BNP and CRP between the two groups were not statistically significantbefore therapy(P>0.05),both of the two indicators in the two groups were significantly decreased after therapy,and the levels of serum BNP and CRP in the observation group were significantly lower than those in the control group(P<0.05).The total effective rate of treatment in the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).The difference of LVEF between the two groups was notstatistically significant(P<0.05),and it significantly improved after therapy,the level of LVEF in the observation group was significantly higher than that in the control group(P<0.05).Conclusions Shenfu injection combined routine therapy may effectively improve the therapeutic effects and protect myocardial function for middle-and old-aged patients with heart failure,which is worthy of clinical application.