家族性与散发性精神分裂症临床及智力功能的对照研究

Comparative study of clinical features and intelligence between the patients with familial and sporadic schizophrenia

目的 :比较家族性与散发性精神分裂症的临床及智力功能。方法 :根据CCMD - 2 -R诊断标准 ,对36例家族性精神分裂症和 76例散发性精神分裂症的临床特点及智力测验结果进行了对比分析。结果 :同散发性精神分裂症相比 ,家族性精神分裂症阴性症状相对突出、智力功能受损较重 (突出表现在领悟、相似性、词汇及图形拼凑等方面 )、疗效不佳。结论 :家族性精神分裂症阴性症状突出 ,智力功能受损较重 ,可能与其遗传学基础有关。

Objective:To compare the clinical feature and intelligence between the patients with familial and sporadic schizophrenia.Methods:36 patients with familial schizophrenia and 76 patients with sporadic schizophrenia were diagnosed according to the CCMD-2-R classification The clinical features and intelligence were compared between the two groups Results:Comparing with the sporadic group,the familial group showed outstanding negative symptom,severe impairment of the intellective function(The distinct manifestation were comprehension,similarity,vocabulary and picture together )and unwell curative effect Conclusion:The outstanding negative symptom and severe impairment of the intellective functon in the familial schizophrenia patients suggested that it may be related to their gentics bases