摘要
目的:探讨分析血清中VEGF的表达与原发性肝癌患者发生肺转移的关系。方法:选取2013年1月~2013年12月间我院收治的原发性肝癌患者50例作为研究对象,并将其设为原发性肝癌组,另选取同期来我院进行健康体检的体检者30例作为正常志愿者组,应用定量ELISA法检测两组研究对象血清中VEGF的含量,观察对比两组研究对象的检测结果,并将对比的结果及两组研究对象的临床资料进行回顾性的分析。结果:原发性肝癌组50例患者血清中VEGF的含量为(326.32±76.3)pg/ml,正常志愿者组30例体检者血清中VEGF的含量为(82.43±26.3)pg/ml,原发性肝癌组患者血清中VEGF的含量明显高于正常志愿者组体检者,差异显著(P<0.01),具有统计学意义。发生肺转移患者血清中VEGF的含量明显高于未发生肺转移患者血清中VEGF的含量,差异显著(P<0.01),具有统计学意义。结论:血清中VEGF的表达可作为预测肝癌患者发生肺转移的一个重要指标。
Objective To explore the relationship between serum VEGF and lung metastasis in hepatocellular carcinoma(HCC). Methods The serum VEGF level of samples including 50 cases with HCC and 30 healthy cases were detected quantitatively with ELISA.The results were evaluated by analyzing the difference of serum VEGF in patients with hepatocellular carcinoma and healthy cases,and investigating the relationship between serum VEGF and lung metastasis in hepatocellular carcinoma. Result The serum VEGF level of HCC was significantly higher than that of healthy cases(P<0.01). The expression of serum VEGF in lung metastasis group was strongly higher than that of no lung metastasis group in before and after treatment(operation and intervention)(P<0.05). Conclusion Serum VEGF level is a potential parameter to indicate the risk of lung metastasis.
基金
国家自然基金(81272173)
福建省自然基金(2012J01358)
