摘要
目的:探讨分析应用硝苯地平联合卡托普利治疗高血压的临床疗效及安全性。方法:选取2012年6月~2013年6月间我院收治的高血压患者120例作为研究对象,采用随机数字表法将其分为对照组(60例)和观察组(60例),单纯应用硝苯地平为对照组患者进行治疗,联合应用硝苯地平和卡托普利为观察组患者进行治疗,观察对比两组患者的临床疗效,并将对比的结果及两组患者的临床资料进行回顾性的分析。结果:在观察组60例患者中,临床疗效判定等级为显效的患者有47例(占患者总数的78.4%),临床疗效判定等级为好转的患者有11例(占患者总数的18.3%),临床疗效判定等级为无效的患者有2例(占患者总数的3.3%),治疗的总有效率为96.7%;在对照组60例患者中,临床疗效判定等级为显效的患者有31例(占患者总数的51.7%),临床疗效判定等级为好转的患者有18例(占患者总数的30.0%),临床疗效判定等级为无效的患者有11例(占患者总数的18.3%),治疗的总有效率为81.7%。观察组患者的临床疗效明显优于对照组患者,差异显著(P<0.05),具有统计学意义。在用药治疗期间,观察组60例患者中无一例患者发生药物不良反应,不良反应的发生率为0%;而在对照组60例患者中,发生咳嗽的患者有6例,出现面部潮红的患者有3例,出现头晕的患者有1例,不良反应的发生率为16.7%。观察组患者的不良反应发生率明显低于对照组患者,差异显著(P<0.05),具有统计学意义。结论:应用硝苯地平联合卡托普利治疗高血压的临床疗效显著,不良反应的发生率较低,安全性较高,值得在临床上推广应用。
Objective To evaluate the validity and safety of nifedipine combined with captopril in treatment of hypertension. Methods All 120 cases of hypertension in our hospital were randomly divided into observation group and control group. 60 cases of observation group received nifedipine combined with captopril, 60 cases of control group received nifedipine. 4 weeks was a course and the validity and safety was compared. Result The efficiency of observation group was 78.4%, total efficiency was 96.7%, which was significantly higher than that of control group (51.7%, 81.7%), and there was significant difference between two groups (P<0.05). There was no adverse drug reaction in observation group during treatment, which was significantly higher than that of control group (16.7%), and there was significant difference between two groups (P<0.05). Conclusion Nifedipine combined with captopril has the role of synergistically lowering blood pressure in treatment of hypertension, which has high clinical effectiveness, with less adverse reaction, lower complication formation rate, saftey and it is worth clinical extensive application.
