应用经皮病灶清除术联合局部化疗治疗脊柱结核的疗效研究

目的:探讨分析应用经皮病灶清除术联合局部化疗的方法治疗脊柱结核的临床疗效。方法:选取2012年2月至2014年4月间我院收治的脊柱结核患者84例作为研究对象,采用随机数字表法将其分为对照组(42例)和观察组(42例),采用传统开放病灶清除手术为对照组患者进行治疗,采用经皮病灶清除术联合局部化疗的方法为观察组患者进行治疗,观察对比两组患者的临床疗效,并将对比的结果及两组患者的临床资料进行回顾性的分析。结果:观察组患者的手术时间为(61.54±8.94)min,术中出血量为(12.54±6.32)ml,全身化疗时间为(11.65±4.35)月,局部化疗时间为(48.64±21.36)d;对照组患者的手术时间为(125.64±11.24)min,术中出血量为(352.14±15.62)ml,全身化疗时间为(24.61±5.94)月,局部化疗时间为(2.31±0.21)d。观察组患者进行手术治疗的各项临床指标均明显优于对照组患者,差异显著(P<0.05),具有统计学意义。观察组患者治疗的总有效率为92.86%,对照组患者治疗的总有效率为71.43%,观察组患者的临床疗效明显优于对照组患者,差异显著(P<0.05),具有统计学意义。结论:应用经皮病灶清除术联合局部化疗的方法治疗脊柱结核的临床疗效显著,值得在临床上推广使用。

Objective: To probe into the clinical effects of the treatment on spinal tuberculosis by lesions clearing local chemotherapy through skins. Methods: 84 patients who suffered from the spinal tuberculosis and who accepted treatment in our hospital from February 2012 to April 2014 were taken as the research objects, and these patients were randomly divided into the control group and the observation group, with 42 patients in each group. In the control group, they were treated with the traditional open surgical lesion clearing while in the observation group, they were treated with the lesions clearing local chemotherapy through skins. Outcome: The operation time, the amount of bleeding, the time of local chemotherapy, and the time&nbsp;of systemic chemotherapy in the observation group were clearly different from that in the control group(P<0.05). In addition, the whole effective rate in the observation group was 92.86%, comparing with 71.43%in the controal group. Thus, the differences had the statistical significances. Conclusion:The treatment on spinal tuberculosis by lesions clearing local chemotherapy through skins is a safe and effective method, which is good for patients to suffer and should be promoted in the clinic applications.