摘要
目的:探讨分析联合应用贝那普利、呋塞米和多巴胺对顽固性心力衰竭合并利尿剂抵抗患者进行治疗的临床效果。方法 :选取2013年2月~2014年5月间我院收治的顽固性心力衰竭合并利尿剂抵抗的患者74例作为研究对象,采用随机数字表法将其分为对照组(37例)和观察组(37例),为对照组患者进行常规治疗,为观察组患者在进行常规治疗的基础上加用贝那普利、呋塞米和多巴胺进行治疗,观察对比两组患者的临床疗效,并将对比的结果及两组患者的临床资料进行回顾性的分析。结果 :观察组患者治疗的总有效率为75.68%,对照组患者治疗的总有效率为56.76,观察组患者的临床疗效明显优于对照组患者,差异显著(P<0.05),具有统计学意义。治疗前,两组患者各项临床指标之间的差异均不显著(P>0.05),不具有统计学意义。经过7天的治疗,两组患者的各项临床指标(除血肌酐水平外)较治疗前均有明显的改善,且观察组患者的改善程度更为明显,差异显著(P<0.05),具有统计学意义。结论 :联合应用贝那普利、呋塞米和多巴胺对顽固性心力衰竭合并利尿剂抵抗患者进行治疗的临床效果显著,值得在临床上推广应用。
Objective To investigate the effects of ACEI and frusemide continued dopamine in treating diuretic resistance of patients with heart failure.Methods 74 patients were selected as researching objects who were randomly divided into two groups, the observation group(n=37)and the control group(n=37).The observation group were given by ACEI complicated with dopamine and frusemide, and the control group were treated by general treatment. The LVEF,the volume of urine and the weight were observed.Results The total effective rate in the observation group was higher than the control group. There were improvements in LVEF,the volume of urine and the weight after treatment, and the observationgroup increased more obviously than that of the control group.Conclusion ACEI complicated with dopamine and frusemide to cure the diuretic resistance in patients with heart failure can improve heart function and diuretic resistance.
