摘要
目的 :分析肝硬化与内毒素血症的相关性。方法 :将2013年2月至2014年7月我院收治的80例肝硬化患者纳入肝硬化组(其中有36例患者并发感染,有44例患者未并发感染)。对这80例患者进行Child-Pugh分级,将其中39例Child-Pugh B级患者纳入Child-Pugh B级组,将其中28例Child-Pugh C级患者纳入Child-Pugh C级组。选取80例健康人作为正常组。采集肝硬化组患者和正常组受试者的血液,应用动态浊度法进行内毒素含量的测定。结果 :肝硬化组与正常组受试者血液中内毒素的含量经独立样本t检验相比较,差异显著(P<0.01),有统计学意义,肝硬化组患者血液中内毒素的含量较高。对肝硬化组患者血液中内毒素的含量与其Child-Pugh分级(B级与C级)的关系进行统计学分析,结果显示:Child-Pugh B级组患者与Child-Pugh C级组患者血中内毒素的含量相比较,差异不显著(P>0.05),无统计学意义。肝硬化组患者中并发感染的患者与未并发感染的患者血液中内毒素的含量经秩和检验相比较,差异显著(P<0.05),有统计学意义。结论 :肝硬化患者,尤其是并发感染的此病患者发生内毒素血症的几率较高。
Aim To find the Clinical features and tendency of Endotoxin in Patients with Liver Cirrhosis and the normal people. Methods Endotoxin were measured in 80 patients with liver cirrhosis and 80 healthy people by kinetic turbidimetric assay (KTA).Results The level of endotoxin were measured in 80 patients with liver cirrhosis by kinetic turbidimetric assay (KTA). The results showed that endotoxin level were significantly increased in patients with liver cirrhosis compared with healthy people. Conclusion The patients with liver cirrhosis are inclined to get endotoxemia.
