摘要
目的:比较用右美托咪定与咪达唑仑对行机械通气的连枷胸合并肺损伤患者进行镇静治疗的临床效果。方法 :对2013年1月~2015年1月期间在我院接受机械通气治疗的26例连枷胸合并肺损伤患者的临床资料进行回顾性研究。我院按照随机数表法将这些患者分为对照组和观察组,每组各有13例患者。我院对对照组患者使用咪达唑仑进行镇静治疗,对观察组患者使用右美托咪定进行镇静治疗,然后比较对两组患进行镇静治疗的效果。结果:这两组患者在接受镇静治疗后,观察组患者在心率、平均动脉压的水平以及进行重症监护的时间、进行机械通气的时间、芬太尼的使用量等方面均明显优于对照组患者,差异显著(P<0.05),具有统计学意义。结论 :与使用咪达唑仑对行机械通气的连枷胸合并肺损伤患者进行镇静治疗的效果相比,使用右美托咪定对其进行镇静治疗的效果更明显,更值得在临床上推广应用。
objective Study of dexmedetomidine in patients with flail chest and pulmonary injury sedative effect.Methods We selected 26 cases of flail chest and pulmonary injury patients, according to the drug use is divided into dexmedetomidine and midazolam group with 13 cases in each group, compared two groups of patients with treatment.Results Dexmedetomidine group after treatment 6 h, 24 h of heart rate and mean arterial pressure were significantly lower than that of midazolam group, with significant difference (P < 0.05); the two groups of patients with 48h heart rate and mean arterial pressure had no significant difference (P > 0.05); the amount of use of dexmedetomidine group ICU patients hospitalization time, offline time and fentanyl were significantly lower than with midazolam group, with significant difference (P < 0.05). 12 cases of dexmedetomidine group out of danger to ordinary ward requirement, slightly more than 9 cases of midazolam group, the difference was not statistically significant (P > 0.05).Conclusion Dexmedetomidine sedation effect is positive, and can enhance the analgesic effect of fentanyl, further reduce dosage, reduce respiratory inhibition, reduce adverse reaction, shorten the duration of hospitalization in ICU and the use of respirator time, worthy of research and application of clinical deepen.
