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浅析肝内胆管结石合并肝内胆管细胞癌患者的临床特点及预后

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摘要 目的 :探讨肝内胆管结石合并肝内胆管细胞癌患者的临床特点及预后。方法 :选取2013年10月至2015年10月期间菏泽医学专科学校教学医院收治的200例肝内胆管细胞癌患者作为研究对象。将其中合并肝内胆管结石的50例肝内胆管细胞癌患者作为研究组。将其中未合并肝内胆管结石的150例肝内胆管细胞癌患者作为对照组。计算两组患者中不同性别患者所占的比例。比较两组患者血清总胆红素(TBIL)、碱性磷酸酶(ALP)、谷氨酰胺转肽酶(γ-GT)、谷丙转氨酶(ALT)及谷草转氨酶(AST)的水平,观察其进行消化道肿瘤抗原19-9(GA19-9)及甲胎蛋白试验的结果。对两组患者均进行手术治疗,观察其术后不同时间的生存率。结果 :研究组患者中女性患者所占的比例、GA19-9试验结果为阴性患者所占的比例均低于对照组患者中相应患者所占的比例,P <0.05。研究组患者中血清ALP水平> 119U/L患者所占的比例、血清γ-GT水平> 64U/L患者所占的比例均高于对照组患者中相应患者所占的比例,P <0.05。研究组患者术后1年的生存率、术后2年的生存率及术后3年的生存率均低于对照组患者,P <0.05。结论 :与未合并肝内胆管结石的肝内胆管细胞癌患者相比,肝内胆管结石合并肝内胆管细胞癌患者中女性患者、GA19-9试验结果为阴性患者所占的比例较低,其中血清ALP水平> 119 U/L患者所占的比例、血清γ-GT水平> 64 U/L患者所占的比例较高,其生存率较低。
出处 《当代医药论丛》 2019年第14期81-82,共2页
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