对十二指肠胃反流与胃黏膜炎症反应相关性的研究

To study the correlation between duodenal gastric reflux and gastric mucosal inflammation

目的:探讨十二指肠胃反流与胃黏膜炎症反应的相关性。方法:将2017年10月至2018年7月期间蒲江县中医医院收治76例十二指肠胃反流患者和同期在该院进行健康体检的62例体检者作为研究对象。按照对患者进行24h胃内胆红素监测的结果将这76例十二指肠胃反流患者分为低反流组(n=36)和高反流组(n=40),将62例体检者作为对照组。对三组研究对象均进行血清炎性因子检测和胃液炎性因子检测,并对其检测的结果进行分析研究,从中找出十二指肠胃反流与胃黏膜炎症反应的相关性。结果:低反流组患者和高反流组患者血清中肿瘤坏死因子α(TNF-α)的水平、白介素-6(IL-6)的水平、白介素-10(IL-10)的水平和胃液中TNF-α的水平、IL-6的水平、IL-10的水平均高于对照组体检者,P <0.05。高反流组患者血清中TNF-α的水平、IL-6的水平、IL-10的水平和胃液中TNF-α的水平、IL-6的水平、IL-10的水平均高于低反流组患者,P <0.05。对其进行Pearson相关性分析的结果显示,十二指肠胃反流患者反流的程度越严重其血液中及胃液中TNF-α的水平、IL-6的水平和IL-10的水平越高。结论:十二指肠胃反流与胃黏膜炎症反应呈正相关,即十二指肠胃反流患者反流的程度越严重其胃黏膜的炎症反应越明显。

Objective:To investigate the correlation between duodenal gastric reflux and gastric mucosal inflammation.Methods:76 patients with duodenal and gastric reflux admitted to pujiang county hospital of traditional Chinese medicine from October 2017 to July 2018 and 62 patients who underwent physical examination in the hospital during the same period were studied.The 76 patients with duodenal and gastric reflux were divided into low reflux group(n=36)and high reflux group(n=40)according to the results of 24 h intragastric bilirubin monitoring.Serum inflammatory factor test and gastric fluid inflammatory factor test were carried out on all three groups of subjects,and the results were analyzed to find out the correlation between duodenal gastric reflux and gastric mucosal inflammatory reaction.Results:serum levels of tumor necrosis factor alpha(tnf-alpha),interleukin-6(il-6),interleukin-10(il-10),and stomach fluid levels of tnf-alpha,il-6,and il-10 in both the low reflux group and the high reflux group were higher than those in the control group(P<0.05).The serum levels of tnf-alpha,il-6 and il-10,as well as the levels of tnf-alpha,il-6 and il-10 in gastric juice in patients with high reflux group were all higher than those in patients with low reflux group(P<0.05).Pearson correlation analysis showed that patients with duodenal gastric reflux had higher levels of tnf-alpha,il-6 and il-10 in the blood and gastric juice.Conclusion:there is a positive correlation between duodenal gastric reflux and gastric mucosal inflammation,that is,the more severe the degree of reflux in patients with duodenal gastric reflux,the more obvious the gastric mucosal inflammation.