1,6-二磷酸果糖镁中镁的药代动力学

A pharmacokinetic study on magnesium of fructose 1,6 diphosphate magnesium

目的 :测定静脉注射 1,6 -二磷酸果糖镁 (fructose 1,6diphosphatemagnesium ,FDP -Mg)中镁的药代动力学特点。方法 :用原子吸收光谱法测定FDP -Mg给药前后家兔血浆总镁的变化情况 ,利用 3P87程序判断它们的房室模型类型 ,并计算相关的药代动力学参数。结果 :FDP -Mg的房室模型为二室模型 ;A、B、α、β分别为 1 2 2mmol·L- 1、0 5 2mmol·L- 1、0 2 9min- 1和 0 0 0 9min- 1。FDP -Mg中Mg的分布容积Vd、Vc、Vp 和Vss均小于 0 2L·kg- 1,分布速率常数k12 、k2 1、k10 分别为0 175、0 0 91、0 0 2 8min- 1,t1/2α、t1/2 β分别为 2 4 2、77 1min ,清除率 (Cl)为 1 7mL·(kg·min) - 1。结论 :FDP -Mg中的Mg的房室模型为二室模型 ,在体内分布迅速 ,在周边室停留的时间相对较长 ,对组织的亲和力较弱 ,药物消除相对较快。

Aim: To determine the pharmacokinetic characteristics of magnesium of fructose 1,6 diphosphate magnesium (FDP-Mg) by intravenous injection. Methods: Total concentration of plasma magnesium before and after intravenous administration was determined by using atomic absorption method. The compartment model and pharmacokinetic parameters were computed by program 3P87. Results: FDP-Mg follows two-compartment model. The values of A,B,α and β are 1.22 mmol·L^(-1), 0.52 (mmol·L^(-1),)0.29 min^(-1) and 0.009 min^(-1) respectively. The V_d, V_c, V_p and V_(ss) of Mg of FDP-Mg are all less than 0.2 L·kg^(-1). The k_(12), k_(21) and k_(10) are 0.175, 0.091 and 0.028 min^(-1) respectively. The t_(1/2α) and t_(1/2β) are 2.42 are 77.1 min. The Cl is 1.7 mL·(kg·min)^(-1). Conclusion: The Mg of FDP-Mg follows two-compartment model. It distributes rapidly in the body, remains longer in the peripheral compartment, has less affinity to tissue and its elimination is faster as well.